Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.
Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, Wojska Polskiego 48, 60-627 Poznan, Poland.
Molecules. 2023 Jul 4;28(13):5209. doi: 10.3390/molecules28135209.
Hesperidin is a polyphenol derived from citrus fruits that has a broad potential for biological activity and the ability to positively modify the intestinal microbiome. However, its activity is limited by its low solubility and, thus, its bioavailability-this research aimed to develop a zein-based hesperidin system with increased solubility and a sustained release profile. The study used triple systems enriched with solubilizers to maximize solubility. The best system was the triple system hesperidin-zein-Hpβ-CD, for which the solubility improved by more than six times. A significant improvement in the antioxidant activity and the ability to inhibit α-glucosidase was also demonstrated, due to an improved solubility. A release profile analysis was performed in the subsequent part of the experiments, confirming the sustained release profile of hesperidin, while improving the solubility. Moreover, the ability of selected probiotic bacteria to metabolize hesperidin and the effect of this flavonoid compound on their growth were investigated.
橙皮苷是一种源自柑橘类水果的多酚，具有广泛的生物活性潜力，并能积极改善肠道微生物组。然而，其活性受到低溶解度的限制，因此生物利用度也受到限制——本研究旨在开发一种基于玉米醇溶蛋白的橙皮苷系统，以提高其溶解度和缓释特性。该研究使用了富含增溶剂的三元体系来最大限度地提高溶解度。最好的系统是橙皮苷-玉米醇溶蛋白-Hpβ-CD 的三元体系，其溶解度提高了六倍以上。由于溶解度的提高，抗氧化活性和抑制α-葡萄糖苷酶的能力也显著提高。在实验的后续部分进行了释放特性分析，证实了橙皮苷的缓释特性，同时提高了溶解度。此外，还研究了选定益生菌的代谢橙皮苷的能力以及这种类黄酮化合物对其生长的影响。
