Zhu Tong, Zhang Baixi, Feng Yan, Li Zhaofeng, Tang Xiaoshu, Ban Xiaofeng, Kong Haocun, Li Caiming
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Key Laboratory of Synergetic and Biological Colloids, Ministry of Education, Wuxi 214122, China.
Foods. 2022 Apr 13;11(8):1118. doi: 10.3390/foods11081118.
Globally, obesity and its metabolic complications, which are intimately linked to diet, are major public health problems. Cyclodextrins (CDs) are cyclic oligosaccharides consisting of (α-1,4)-linked D-glucopyranose units that can reduce fat bioavailability and affect metabolism by improving intestinal flora as prebiotics. We compared the effects of three CDs on preventing fat accumulation and remodeling gut microbiota in a high-fat diet-fed C57BL/6J mouse model. α-CD maximized energy expenditure by 12.53%, caused the RER value to drop from 0.814 to 0.788, and increased the proportion of fatty acid oxidation for energy supply. β-CD supplementation resulted in a marked 24.53% reduction in weight gain and a decrease in epididymal-fat-relative weight from 3.76% to 2.09%. It also minimized ectopic fat deposition and improved blood lipid parameters. γ-CD maximized the concentration of SCFAs in the cecum from 6.29 to 15.31 μmol/g. All three CDs reduced the abundance ratio of Firmicutes and Bacteroidetes to a low-fat diet level, increased the abundance of and , and reduced the abundance of and . These findings imply that a combination of multiple CDs may exert superior effects as a potential strategy for obesity prevention.
在全球范围内，肥胖及其代谢并发症与饮食密切相关，是主要的公共卫生问题。环糊精（CDs）是由（α-1,4）连接的D-吡喃葡萄糖单元组成的环状寡糖，作为益生元，可降低脂肪生物利用度并通过改善肠道菌群影响新陈代谢。我们比较了三种环糊精对高脂饮食喂养的C57BL/6J小鼠模型预防脂肪堆积和重塑肠道微生物群的影响。α-环糊精使能量消耗最大化12.53%，导致呼吸商（RER）值从0.814降至0.788，并增加了用于能量供应的脂肪酸氧化比例。补充β-环糊精使体重增加显著降低24.53%，附睾脂肪相对重量从3.76%降至2.09%。它还使异位脂肪沉积最小化并改善了血脂参数。γ-环糊精使盲肠中短链脂肪酸（SCFAs）的浓度从6.29μmol/g最大化至15.31μmol/g。所有三种环糊精都将厚壁菌门和拟杆菌门的丰度比降低到低脂饮食水平，增加了[具体菌属1]和[具体菌属2]的丰度，并降低了[具体菌属3]和[具体菌属4]的丰度。这些发现表明，多种环糊精联合使用作为预防肥胖的潜在策略可能会发挥更好的效果。
