• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

新型发酵过程软测量建模方法的开发与优化。

Development and Optimization of a Novel Soft Sensor Modeling Method for Fermentation Process of .

机构信息

Key Laboratory of Agricultural Measurement and Control Technology and Equipment for Mechanical Industrial Facilities, School of Electrical and Information Engineering, Jiangsu University, Zhenjiang 212013, China.

出版信息

Sensors (Basel). 2023 Jun 29;23(13):6014. doi: 10.3390/s23136014.

DOI:10.3390/s23136014
PMID:37447863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10346157/
Abstract

This paper introduces a novel soft sensor modeling method based on BDA-IPSO-LSSVM designed to address the issue of model failure caused by varying fermentation data distributions resulting from different operating conditions during the fermentation of different batches of . First, the problem of significant differences in data distribution among different batches of the fermentation process is addressed by adopting the balanced distribution adaptation (BDA) method from transfer learning. This method reduces the data distribution differences among batches of the fermentation process, while the fuzzy set concept is employed to improve the BDA method by transforming the classification problem into a regression prediction problem for the fermentation process. Second, the soft sensor model for the fermentation process is developed using the least squares support vector machine (LSSVM). The model parameters are optimized by an improved particle swarm optimization (IPSO) algorithm based on individual differences. Finally, the data obtained from the fermentation experiment are used for simulation, and the developed soft sensor model is applied to predict the cell concentration and product concentration during the fermentation process of . Simulation results demonstrate that the IPSO algorithm has good convergence performance and optimization performance compared with other algorithms. The improved BDA algorithm can make the soft sensor model adapt to different operating conditions, and the proposed soft sensor method outperforms existing methods, exhibiting higher prediction accuracy and the ability to accurately predict the fermentation process of under different operating conditions.

摘要

本文提出了一种基于 BDA-IPSO-LSSVM 的软测量建模新方法,旨在解决由于不同批次发酵过程中不同操作条件导致发酵数据分布变化而引起的模型失效问题。首先,通过采用迁移学习中的平衡分布适应(BDA)方法来解决发酵过程中不同批次数据分布差异较大的问题。该方法减少了发酵过程中不同批次的数据分布差异,同时利用模糊集概念,将分类问题转化为发酵过程的回归预测问题,改进了 BDA 方法。其次,采用最小二乘支持向量机(LSSVM)构建发酵过程的软测量模型。采用基于个体差异的改进粒子群优化(IPSO)算法对模型参数进行优化。最后,利用发酵实验获得的数据进行仿真,将开发的软测量模型应用于预测发酵过程中的细胞浓度和产物浓度。仿真结果表明,与其他算法相比,IPSO 算法具有良好的收敛性能和优化性能。改进的 BDA 算法可以使软测量模型适应不同的操作条件,所提出的软测量方法优于现有方法,具有更高的预测精度,能够准确预测不同操作条件下的发酵过程。

相似文献

1
Development and Optimization of a Novel Soft Sensor Modeling Method for Fermentation Process of .新型发酵过程软测量建模方法的开发与优化。
Sensors (Basel). 2023 Jun 29;23(13):6014. doi: 10.3390/s23136014.
2
Modeling and Optimization of an Enhanced Soft Sensor for the Fermentation Process of .建立.发酵过程增强型软测量模型与优化
Sensors (Basel). 2024 May 9;24(10):3017. doi: 10.3390/s24103017.
3
A soft sensor model of cell concentration based on IBDA-RELM.基于 IBDA-RELM 的细胞浓度软测量模型。
Prep Biochem Biotechnol. 2022;52(6):618-626. doi: 10.1080/10826068.2021.1980799. Epub 2021 Oct 20.
4
Study on Multi-Model Soft Sensor Modeling Method and Its Model Optimization for the Fermentation Process of .基于 的发酵过程多模型软测量建模方法及其模型优化研究
Sensors (Basel). 2021 Nov 17;21(22):7635. doi: 10.3390/s21227635.
5
Research on soft sensing method of photosynthetic bacteria fermentation process based on ant colony algorithm and least squares support vector machine.基于蚁群算法和最小二乘支持向量机的光合细菌发酵过程软测量方法研究
Prep Biochem Biotechnol. 2023;53(4):341-352. doi: 10.1080/10826068.2022.2090002. Epub 2022 Jul 11.
6
Biomass soft sensor for a Pichia pastoris fed-batch process based on phase detection and hybrid modeling.基于相检测和混合建模的毕赤酵母分批发酵过程生物质软传感器。
Biotechnol Bioeng. 2020 Sep;117(9):2749-2759. doi: 10.1002/bit.27454. Epub 2020 Jul 11.
7
Accurate and cost-effective prediction of HBsAg titer in industrial scale fermentation process of recombinant Pichia pastoris by using neural network based soft sensor.利用基于神经网络的软测量技术,在重组毕赤酵母工业规模发酵过程中准确且经济地预测 HBsAg 效价。
Biotechnol Appl Biochem. 2019 Jul;66(4):681-689. doi: 10.1002/bab.1785. Epub 2019 Jun 24.
8
An online soft sensor method for biochemical reaction process based on JS-ISSA-XGBoost.基于 JS-ISSA-XGBoost 的生化反应过程在线软测量方法。
BMC Biotechnol. 2023 Nov 8;23(1):49. doi: 10.1186/s12896-023-00816-3.
9
Soft-sensor modeling for L-lysine fermentation process based on hybrid ICS-MLSSVM.基于混合 ICS-MLSSVM 的 L-赖氨酸发酵过程软测量建模。
Sci Rep. 2020 Jul 15;10(1):11630. doi: 10.1038/s41598-020-68081-4.
10
Codon pair optimization (CPO): a software tool for synthetic gene design based on codon pair bias to improve the expression of recombinant proteins in Pichia pastoris.密码子对优化 (CPO):一种基于密码子对偏好的用于合成基因设计的软件工具,用于提高毕赤酵母中重组蛋白的表达。
Microb Cell Fact. 2021 Nov 4;20(1):209. doi: 10.1186/s12934-021-01696-y.

引用本文的文献

1
Modeling and Optimization of an Enhanced Soft Sensor for the Fermentation Process of .建立.发酵过程增强型软测量模型与优化
Sensors (Basel). 2024 May 9;24(10):3017. doi: 10.3390/s24103017.
2
Intelligent Soft Sensors.智能软传感器
Sensors (Basel). 2023 Aug 3;23(15):6895. doi: 10.3390/s23156895.

本文引用的文献

1
Soft-Sensing Regression Model: From Sensor to Wafer Metrology Forecasting.软传感回归模型:从传感器到晶圆计量预测
Sensors (Basel). 2023 Oct 10;23(20):8363. doi: 10.3390/s23208363.
2
Study on Multi-Model Soft Sensor Modeling Method and Its Model Optimization for the Fermentation Process of .基于 的发酵过程多模型软测量建模方法及其模型优化研究
Sensors (Basel). 2021 Nov 17;21(22):7635. doi: 10.3390/s21227635.
3
A soft sensor model of cell concentration based on IBDA-RELM.基于 IBDA-RELM 的细胞浓度软测量模型。
Prep Biochem Biotechnol. 2022;52(6):618-626. doi: 10.1080/10826068.2021.1980799. Epub 2021 Oct 20.
4
A Deep Probabilistic Transfer Learning Framework for Soft Sensor Modeling With Missing Data.一种用于带缺失数据的软传感器建模的深度概率迁移学习框架。
IEEE Trans Neural Netw Learn Syst. 2022 Dec;33(12):7598-7609. doi: 10.1109/TNNLS.2021.3085869. Epub 2022 Nov 30.
5
Nitrogen supplementation ameliorates product quality and quantity during high cell density bioreactor studies of Pichia pastoris: A case study with proteolysis prone streptokinase.在毕赤酵母高密度生物反应器研究中,氮源补充可以改善产物质量和数量:以易蛋白水解的链激酶为例。
Int J Biol Macromol. 2021 Jun 1;180:760-770. doi: 10.1016/j.ijbiomac.2021.03.021. Epub 2021 Mar 11.
6
RNN- and LSTM-Based Soft Sensors Transferability for an Industrial Process.基于 RNN 和 LSTM 的工业过程软传感器可转移性。
Sensors (Basel). 2021 Jan 26;21(3):823. doi: 10.3390/s21030823.
7
Modern Soft-Sensing Modeling Methods for Fermentation Processes.现代发酵过程软测量建模方法。
Sensors (Basel). 2020 Mar 23;20(6):1771. doi: 10.3390/s20061771.
8
Pichia pastoris: A highly successful expression system for optimal synthesis of heterologous proteins.毕赤酵母:一种高效的表达系统,可用于最优合成异源蛋白。
J Cell Physiol. 2020 Sep;235(9):5867-5881. doi: 10.1002/jcp.29583. Epub 2020 Feb 14.
9
Domain adaptation via transfer component analysis.通过迁移成分分析实现领域自适应。
IEEE Trans Neural Netw. 2011 Feb;22(2):199-210. doi: 10.1109/TNN.2010.2091281. Epub 2010 Nov 18.