Kim Youn Jin, Lee Ji Eun, Jang Hye Sung, Hong Sung Yun, Lee Jun Bae, Park Seo Yeon, Hwang Jae Sung
Department of Genetic Engineering & Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Youngin 17104, Republic of Korea.
COSMAX R&I Center, Seongnam 13486, Republic of Korea.
Biomol Ther (Seoul). 2021 Mar 1;29(2):220-226. doi: 10.4062/biomolther.2020.106.
The role of particulate matter (PM) in health problems including cardiovascular diseases (CVD) and pneumonia is becoming increasingly clear. Polycyclic aromatic hydrocarbons, major components of PM, bind to aryl hydrocarbon receptor (AhRs) and promote the expression of CYP1A1 through the AhR pathway in keratinocytes. Activation of AhRs in skin cells is associated with cell differentiation in keratinocytes and inflammation, resulting in dermatological lesions. Oleanolic acid, a natural component of , also has anti-inflammation, anticancer, and antioxidant characteristics. Previously, we found that PM induced the AhR signaling pathway and autophagy process in keratinocytes. Here, we investigated the effects of oleanolic acid on PM-induced skin aging. We observed that oleanolic acid inhibits PM-induced CYP1A1 and decreases the increase of tumor necrosis factor- alpha and interleukin 6 induced by PM. A supernatant derived from keratinocytes cotreated with oleanolic acid and PM inhibited the release of matrix metalloproteinase 1 in dermal fibroblasts. Also, the AhR-mediated autophagy disruption was recovered by oleanolic acid. Thus, oleanolic acid may be a potential treatment for addressing PM-induced skin aging.
颗粒物（PM）在包括心血管疾病（CVD）和肺炎在内的健康问题中所起的作用正变得越来越清晰。多环芳烃是PM的主要成分，它与芳烃受体（AhRs）结合，并通过角质形成细胞中的AhR途径促进CYP1A1的表达。皮肤细胞中AhRs的激活与角质形成细胞的细胞分化和炎症相关，从而导致皮肤病变。齐墩果酸作为[此处原文缺失相关内容]的天然成分，也具有抗炎、抗癌和抗氧化特性。此前，我们发现PM可诱导角质形成细胞中的AhR信号通路和自噬过程。在此，我们研究了齐墩果酸对PM诱导的皮肤衰老的影响。我们观察到，齐墩果酸可抑制PM诱导的CYP1A1，并减少PM诱导的肿瘤坏死因子-α和白细胞介素6的增加。与齐墩果酸和PM共同处理的角质形成细胞产生的上清液可抑制真皮成纤维细胞中基质金属蛋白酶1的释放。此外，齐墩果酸可恢复AhR介导的自噬破坏。因此，齐墩果酸可能是一种治疗PM诱导的皮肤衰老的潜在药物。
