Virginia Commonwealth University School of Medicine, Richmond, 23298 VA, USA.
Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University School of Pharmacy, Richmond, 23298 VA, USA.
Biomark Med. 2023 Apr;17(8):445-454. doi: 10.2217/bmm-2023-0172. Epub 2023 Jul 14.
Nonalcoholic fatty liver disease (NAFLD) is currently the most common form of chronic liver disease. The growing prevalence of NAFLD is strongly associated with the high incidence of metabolic syndrome. NAFLD affects as much as 19% of the US population with a disproportionate impact on minority racial groups such as Asian Americans. If not promptly managed, NAFLD may progress to more feared complications. Liver indices for NAFLD screening have been proposed but were often developed using study populations with different anthropometrics than patients of East Asian descent. This review compares the accuracy of five indices for NAFLD screening in Asian cohorts. The Fatty Liver Index performed well in multiple large-scale community studies, although other indices may be more suited for specific patient cohorts. This is important, as the utilization of liver indices could accelerate screening for NAFLD for early management and to reduce liver disease-related health disparities among Asian Americans.
非酒精性脂肪性肝病（NAFLD）是目前最常见的慢性肝病。NAFLD 的发病率不断上升，与代谢综合征的高发密切相关。NAFLD 影响着多达 19%的美国人口，对亚裔美国人等少数族裔的影响不成比例。如果不及时治疗，NAFLD 可能会发展为更可怕的并发症。已经提出了用于筛查 NAFLD 的肝脏指数，但这些指数通常是使用与东亚裔患者不同的人体测量学的研究人群开发的。本综述比较了五种用于亚洲人群筛查 NAFLD 的指数的准确性。脂肪性肝病指数在多项大规模社区研究中表现良好，尽管其他指数可能更适合特定的患者群体。这一点很重要，因为肝脏指数的使用可以加速对 NAFLD 的筛查，以便进行早期管理，并减少亚裔美国人中与肝脏疾病相关的健康差距。
