长期使用二肽基肽酶-4抑制剂导致的伴有继发性巨细胞动脉炎的缓解性血清阴性对称性滑膜炎伴凹陷性水肿综合征。
RS3PE Syndrome with Subsequent PMR Caused by Long-Term DPP-4 Inhibitor Use.
作者信息
Takahashi Yuichi, Deshpande Gautam A, Kanai Yoshinori, Seok Yan Kwang, Naito Toshio
机构信息
Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.
出版信息
Eur J Case Rep Intern Med. 2023 Jun 12;10(7):003914. doi: 10.12890/2023_003914. eCollection 2023.
UNLABELLED
Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome has been reported in patients treated with dipeptidyl peptidase-4 inhibitors (DPP-4i). We experienced a case of RS3PE syndrome in a 73-year-old man with a history of type 2 diabetes, who developed RS3PE as a side effect of vildagliptin. Further to this, the patient developed polymyalgia rheumatica (PMR), the first such case associated with long-term DPP-4i use.
LEARNING POINTS
RS3PE syndrome and PMR are rare diseases that cause painful extremities in adults. We need to know if it occurs by DPP-4i.RS3PE syndrome and PMR can be complicated with malignancy or giant cell arteritis. However, we must rule out side effects of drugs at first from the standpoint of medical resources.
未标注
有报道称，在使用二肽基肽酶-4抑制剂（DPP-4i）治疗的患者中出现了伴有凹陷性水肿的缓解型血清阴性对称性滑膜炎（RS3PE）综合征。我们遇到了一名73岁的2型糖尿病男性患者发生RS3PE综合征的病例，他因使用维格列汀而出现RS3PE作为副作用。此外，该患者还出现了风湿性多肌痛（PMR），这是首例与长期使用DPP-4i相关的病例。
学习要点
RS3PE综合征和PMR是导致成人肢体疼痛的罕见疾病。我们需要了解其是否由DPP-4i引起。RS3PE综合征和PMR可能并发恶性肿瘤或巨细胞动脉炎。然而，从医疗资源的角度来看，我们首先必须排除药物的副作用。
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