Nguyen Minh-Trung, Thi Bich Huyen Bui, Maskey Shila, Tran Minh-Dinh, Nguyen Quang-Vinh
Institute of Biotechnology and Environment Tay Nguyen University Buon Ma Thuot Vietnam.
Faculty of Natural Science and Technology Tay Nguyen University Buon Ma Thuot Vietnam.
Food Sci Nutr. 2023 Apr 26;11(7):3875-3884. doi: 10.1002/fsn3.3373. eCollection 2023 Jul.
L. (DC) () has been used in antidiabetes treatment for ages. However, the scientific evidence of active agents that have antidiabetic activity and response against biological activities is limited. In this study, the active components of SZL trunk-bark extract ( extract) were identified using principal component analysis (PCA), and their antidiabetic activities were assessed. The results indicated that the ethyl acetate fraction (EAF) had the highest concentration of phenolic compounds, antioxidants, and antihyperglycemic activities in the postprandial zebrafish model. The major antioxidant contributors were gallic acid, catechin, epicatechin, ellagic acid, quercetin, caffeine, and apigenin, and their concentrated levels reduced α-amylase inhibitory activity, whereas rutin and ethyl gallate influenced the α-glucosidase inhibitory activity. This study showed the bio-functional properties of active phenolic compounds present in the extract, potentially serving as a functional food to control hyperglycemia.
L. (DC) () 长期以来一直用于抗糖尿病治疗。然而，具有抗糖尿病活性以及针对生物活性的反应的活性剂的科学证据有限。在本研究中，使用主成分分析（PCA）鉴定了SZL树皮提取物（提取物）的活性成分，并评估了它们的抗糖尿病活性。结果表明，在餐后斑马鱼模型中，乙酸乙酯馏分（EAF）具有最高浓度的酚类化合物、抗氧化剂和降血糖活性。主要的抗氧化剂成分是没食子酸、儿茶素、表儿茶素、鞣花酸、槲皮素、咖啡因和芹菜素，它们的浓缩水平降低了α-淀粉酶抑制活性，而芦丁和没食子酸乙酯影响了α-葡萄糖苷酶抑制活性。本研究展示了提取物中存在的活性酚类化合物的生物功能特性，有可能作为控制高血糖的功能性食品。
