Jewell S A, Di Monte D, Gentile A, Guglielmi A, Altomare E, Albano O
J Hepatol. 1986;3(1):1-6. doi: 10.1016/s0168-8278(86)80139-8.
The metabolism of ethanol can result in depletion of reduced glutathione (GSH) via adduct formation and oxidation to GSSG. In this study, the glutathione concentration in liver tissue of chronic alcoholic patients (n = 20) was measured using a specific chromatographic method. The results are compared to values obtained from a group of selected controls (n = 10), and correlated to liver histology and blood biochemistry. All of the alcoholics had markedly lower hepatic GSH concentrations than the control group (medians = 2.17 vs 3.88 mumol/g liver, respectively). No significant differences in liver GSH were found among alcoholic subgroups who had slightly altered or normal histology and/or blood tests vs those with advanced pathology. A decrease in hepatic GSH concentration seems to be a consistent characteristic of chronic alcohol abuse which occurs even in the absence of evident liver damage.
乙醇的代谢可通过加合物形成以及氧化为氧化型谷胱甘肽（GSSG）导致还原型谷胱甘肽（GSH）耗竭。在本研究中，采用特定的色谱方法测定了20例慢性酒精中毒患者肝脏组织中的谷胱甘肽浓度。将结果与一组选定的对照组（n = 10）所得值进行比较，并与肝脏组织学和血液生化指标相关联。所有酗酒者肝脏GSH浓度均显著低于对照组（中位数分别为2.17和3.88 μmol/g肝脏）。在组织学和/或血液检查略有改变或正常的酗酒亚组与有严重病变的亚组之间，未发现肝脏GSH有显著差异。肝脏GSH浓度降低似乎是慢性酒精滥用的一个一致特征，即使在没有明显肝脏损伤的情况下也会发生。
