College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Cardiology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China.
FASEB J. 2023 Aug;37(8):e23099. doi: 10.1096/fj.202301012R.
The abnormal lipid metabolism in diabetic cardiomyopathy can cause myocardial mitochondrial dysfunction, lipotoxicity, abnormal death of myocardial cells, and myocardial remodeling. Mitochondrial homeostasis and normal lipid metabolism can effectively slow down the development of diabetic cardiomyopathy. Recent studies have shown that SIRT6 may play an important role in the pathological changes of diabetic cardiomyopathy such as myocardial cell death, myocardial hypertrophy, and myocardial fibrosis by regulating mitochondrial oxidative stress and glucose and lipid metabolism. Therefore, understanding the function of SIRT6 and its role in the pathogenesis of diabetic cardiomyopathy is of great significance for exploring and developing new targets and drugs for the treatment of diabetic cardiomyopathy. This article reviews the latest findings of SIRT6 in the pathogenesis of diabetic cardiomyopathy, focusing on the regulation of mitochondria and lipid metabolism by SIRT6 to explore potential clinical treatments.
糖尿病心肌病中的异常脂质代谢可导致心肌线粒体功能障碍、脂毒性、心肌细胞异常死亡和心肌重构。线粒体稳态和正常脂质代谢可以有效地减缓糖尿病心肌病的发展。最近的研究表明，SIRT6 通过调节线粒体氧化应激以及葡萄糖和脂质代谢，可能在心肌细胞死亡、心肌肥大和心肌纤维化等糖尿病心肌病的病理变化中发挥重要作用。因此，了解 SIRT6 的功能及其在糖尿病心肌病发病机制中的作用对于探索和开发治疗糖尿病心肌病的新靶点和药物具有重要意义。本文综述了 SIRT6 在糖尿病心肌病发病机制中的最新研究发现，重点探讨 SIRT6 对线粒体和脂质代谢的调节，以探索潜在的临床治疗方法。
