Lopes Natasha Dos Santos, Santos Ariana Silva, de Novais Diogo Pereira Silva, Pirovani Carlos Priminho, Micheli Fabienne
Departamento de Ciências Biológicas (DCB), Centro de Biotecnologia e Genética (CBG), Universidade Estadual de Santa Cruz (UESC), Ilhéus-Bahia, Brazil.
Centre de Coopération Internationale en Recherche Agronomique pour le Développement (CIRAD), Unité Mixte de Recherche Amélioration Génétique et Adaptation des Plantes Meditérranéennes et Tropicales (UMR AGAP Institut), Montpellier, France.
Front Plant Sci. 2023 Jul 4;14:1193873. doi: 10.3389/fpls.2023.1193873. eCollection 2023.
The Family of pathogenesis-related proteins 10 (PR-10) is widely distributed in the plant kingdom. PR-10 are multifunctional proteins, constitutively expressed in all plant tissues, playing a role in growth and development or being induced in stress situations. Several studies have investigated the preponderant role of PR-10 in plant defense against biotic stresses; however, little is known about the mechanisms of action of these proteins. This is the first systematic review conducted to gather information on the subject and to reveal the possible mechanisms of action that PR-10 perform.
Therefore, three databases were used for the article search: PubMed, Web of Science, and Scopus. To avoid bias, a protocol with inclusion and exclusion criteria was prepared. In total, 216 articles related to the proposed objective of this study were selected.
The participation of PR-10 was revealed in the plant's defense against several stressor agents such as viruses, bacteria, fungi, oomycetes, nematodes and insects, and studies involving fungi and bacteria were predominant in the selected articles. Studies with combined techniques showed a compilation of relevant information about PR-10 in biotic stress that collaborate with the understanding of the mechanisms of action of these molecules. The up-regulation of PR-10 was predominant under different conditions of biotic stress, in addition to being more expressive in resistant varieties both at the transcriptional and translational level.
Biological models that have been proposed reveal an intrinsic network of molecular interactions involving the modes of action of PR-10. These include hormonal pathways, transcription factors, physical interactions with effector proteins or pattern recognition receptors and other molecules involved with the plant's defense system.
The molecular networks involving PR-10 reveal how the plant's defense response is mediated, either to trigger susceptibility or, based on data systematized in this review, more frequently, to have plant resistance to the disease.
病程相关蛋白10（PR - 10）家族广泛分布于植物界。PR - 10是多功能蛋白，在所有植物组织中组成性表达，在生长发育中发挥作用或在胁迫情况下被诱导表达。多项研究探讨了PR - 10在植物抵御生物胁迫中的重要作用；然而，这些蛋白的作用机制却鲜为人知。这是首次进行的系统性综述，旨在收集该主题的信息并揭示PR - 10可能的作用机制。
因此，使用了三个数据库进行文献检索：PubMed、科学网和Scopus。为避免偏差，制定了包含纳入和排除标准的方案。总共筛选出216篇与本研究目标相关的文章。
研究表明PR - 10参与植物对多种胁迫因子的防御，如病毒、细菌、真菌、卵菌、线虫和昆虫，所选文章中涉及真菌和细菌的研究占主导。综合技术研究汇总了关于PR - 10在生物胁迫方面的相关信息，有助于理解这些分子的作用机制。除了在转录和翻译水平上在抗性品种中表达更强外，PR - 10在不同生物胁迫条件下主要表现为上调。
已提出的生物学模型揭示了一个涉及PR - 10作用方式的分子相互作用内在网络。这些包括激素途径、转录因子、与效应蛋白或模式识别受体的物理相互作用以及与植物防御系统相关的其他分子。
涉及PR - 10的分子网络揭示了植物防御反应是如何介导的，要么引发易感性，要么根据本综述整理的数据，更常见的是使植物对疾病产生抗性。
