Harrold Joanne A, Hill Scott, Radu Cristina, Thomas Paul, Thorp Paula, Hardman Charlotte A, Christiansen Paul, Halford Jason C G
Department of Psychology, University of Liverpool, Liverpool, UK.
School of Psychology, University of Leeds, Leeds, UK.
Obesity (Silver Spring). 2023 Aug;31(8):1996-2008. doi: 10.1002/oby.23796.
The aim of this study was to compare non-nutritive sweetened (NNS) beverages versus water for weight loss after a 12-week behavioral weight-management program.
This is an ongoing, 2-year, parallel-group, open-label, controlled equivalence trial; week-12 data are reported. Adults with BMI of 27 to 35 kg/m who regularly drank cold beverages were randomized 1:1 to intention-to-treat water or NNS beverages while undergoing a weekly 12-week group behavioral weight-management program. Weight change to week 12 was the primary end point (equivalence: two-sided p > 0.05); changes in waist and hip circumference, blood pressure, glycemic control markers, fasting lipid profiles, liver function tests, hunger (visual analog scale), sugar and sweetener consumption, and activity levels were secondary end points.
Overall, 493 participants were randomized (water: n = 246; NNS beverages: n = 247); 24.1% were NNS beverage naïve. Weight change was equivalent with water versus NNS beverages (-5.6 vs. -5.8 kg; difference [90% CI]: -0.2 kg [-0.7 to 0.4]). There were no significant differences between groups for secondary end points except reductions in waist circumference (greater with NNS beverages vs. water), glycated hemoglobin, and consumption of any type of sweetener (both greater with water vs. NNS beverages).
Weight loss was equivalent with NNS beverages and water following a 12-week behavioral weight-management program.
本研究旨在比较非营养性甜味（NNS）饮料与水在为期12周的行为体重管理计划后的减肥效果。
这是一项正在进行的、为期2年的平行组、开放标签、对照等效性试验；报告的是第12周的数据。体重指数（BMI）为27至35kg/m²且经常饮用冷饮的成年人，在接受为期12周的每周一次的小组行为体重管理计划时，按1:1随机分配至意向性治疗组，分别饮用白水或NNS饮料。第12周时的体重变化是主要终点（等效性：双侧p>0.05）；腰围和臀围、血压、血糖控制指标、空腹血脂谱、肝功能检查、饥饿感（视觉模拟量表）、糖和甜味剂摄入量以及活动水平的变化是次要终点。
总体而言，493名参与者被随机分组（白水组：n = 246；NNS饮料组：n = 247）；24.1%的参与者此前未饮用过NNS饮料。饮用白水和NNS饮料后的体重变化相当（-5.6 vs. -5.8kg；差异[90%CI]：-0.2kg[-0.7至0.4]）。除腰围减小（NNS饮料组比白水组更明显）、糖化血红蛋白以及任何类型甜味剂的摄入量（白水组均比NNS饮料组更高）外，两组在次要终点方面无显著差异。
在为期12周的行为体重管理计划后，饮用NNS饮料和白水的减肥效果相当。
