一种在自由活动大鼠中进行重复脑脊液采样的方法。
A method for repeated CSF sampling in the freely moving rat.
作者信息
Kornhuber M E, Kornhuber J, Cimniak U
出版信息
J Neurosci Methods. 1986 Jul;17(1):63-8. doi: 10.1016/0165-0270(86)90035-x.
PMID:3747592
Abstract
With the use of a holder mounted on the skull of rats, a cannula can be implanted so that one end rests on the atlanto-occipital membrane overlying the cisterna magna. Needles introduced through the cannula allow repeated access to the cisterna magna in the freely moving animal. This system is stable for periods of up to 4 weeks and is suited for repeated sampling of the cerebrospinal fluid.
摘要
使用安装在大鼠颅骨上的固定器，可以植入一根套管，使一端置于覆盖大池的枕骨大孔膜上。通过套管插入的针头能让实验者在自由活动的动物身上反复进入大池。该系统可稳定使用长达4周，适用于脑脊液的反复采样。
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