Kaufman L N, Corbett S W, Keesey R E
Metabolism. 1986 Sep;35(9):847-51. doi: 10.1016/0026-0495(86)90227-1.
The role of thyroid hormones and norepinephrine in the elevated thermogenesis seen following lateral hypothalamic (LH) lesions was investigated by measuring serum thyroid hormone levels and urinary norepinephrine excretion during the 24 hours following placement of LH lesions and again one month later when body weight had stabilized at a reduced level. During the first 24 hours following LH lesions, serum thyroxine (T4) and triiodothyronine (T3) were significantly depressed. By one month postlesion, both T4 and T3 had returned to normal. In contrast, urinary excretion of norepinephrine (NE) was increased 100% during the 24 hours following LH lesions. By one month postlesion, NE had returned to normal levels. These results indicate that the elevated thermogenesis seen shortly following LH lesions does not reflect enhanced thyroid activity, but is probably a consequence of sympathetic nervous system stimulation. The return of NE to normal levels after one month is consistent with the observation that LH-lesioned rats are by one month postlesion no longer hypermetabolic, but display levels of heat production appropriate to the reduced body weight they then maintain.
通过测量下丘脑外侧区（LH）损伤后24小时内的血清甲状腺激素水平和尿去甲肾上腺素排泄量，并在一个月后体重稳定在较低水平时再次测量，研究了甲状腺激素和去甲肾上腺素在LH损伤后出现的产热增加中的作用。在LH损伤后的最初24小时内，血清甲状腺素（T4）和三碘甲状腺原氨酸（T3）显著降低。损伤后一个月，T4和T3均恢复正常。相比之下，LH损伤后24小时内去甲肾上腺素（NE）的尿排泄量增加了100%。损伤后一个月，NE已恢复到正常水平。这些结果表明，LH损伤后不久出现的产热增加并不反映甲状腺活性增强，而可能是交感神经系统刺激的结果。一个月后NE恢复到正常水平，这与观察结果一致，即LH损伤的大鼠在损伤后一个月不再处于高代谢状态，而是表现出与其维持的较低体重相适应的产热水平。
