阿片肽系统在冠状动脉侧支形成中的作用
The impact of the apelinergic system in coronary collateral formation.
作者信息
Özsoyler İbrahim, Uçak Haci Ali, Badak Tolga Onur, Çakallıoğlu Ahmet, Bayraktar Muhammet, Arslan Ahmet Süha
机构信息
Department of Cardiovascular Surgery, Health Sciences University, Adana Şehir Training and Research Hospital, Adana, Türkiye.
Department of Public Health, Niğde Ömer Halisdemir University Faculty of Medicine, Niğde, Türkiye.
出版信息
Turk Gogus Kalp Damar Cerrahisi Derg. 2023 Apr 7;31(2):192-198. doi: 10.5606/tgkdc.dergisi.2023.24422. eCollection 2023 Apr.
BACKGROUND
This study aims to examine the relationship between the development of coronary collateral circulation and serum elabela levels.
METHODS
Between January 2020 and December 2021, a total of 50 control individuals (29 males, 21 females; mean age: 63.2±10.0 years; range, 52 to 73 years) with no significant coronary artery disease as confirmed by angiography (Group 1) and 100 patients (55 males, 45 females; mean age: 66.6±9.6 years; range, 56 to 75 years) with coronary artery disease were included. The patients were further divided into two equal groups according to the Rentrop classification as poor (Group 2) and good coronary collateral circulation (Group 3). All groups were compared in terms of several parameters, particularly serum elabela levels.
RESULTS
Serum elabela levels were found to be statistically higher in the group with good collateral than the other groups (p<0.05). Low serum elabela levels increased the risk of developing weak collaterals by 2.43 times.
CONCLUSION
The elabela protein is directly related to good collateral development and can be considered a potential agent for treatment.
背景
本研究旨在探讨冠状动脉侧支循环发育与血清elabela水平之间的关系。
方法
在2020年1月至2021年12月期间，纳入了50名经血管造影证实无明显冠状动脉疾病的对照个体（29名男性，21名女性；平均年龄：63.2±10.0岁；范围52至73岁）（第1组）和100例冠状动脉疾病患者（55名男性，45名女性；平均年龄：66.6±9.6岁；范围56至75岁）。根据Rentrop分类，将患者进一步分为两组，即侧支循环差的组（第2组）和侧支循环良好的组（第3组）。比较了所有组的几个参数，特别是血清elabela水平。
结果
发现侧支循环良好组的血清elabela水平在统计学上高于其他组（p<0.05）。血清elabela水平低会使侧支循环薄弱的风险增加2.43倍。
结论
elabela蛋白与良好的侧支循环发育直接相关，可被视为一种潜在的治疗药物。
Zotero 插件