Vandelli C, Bottazzo G F, Doniach D, Franceschi F
N Engl J Med. 1979 Jun 21;300(25):1406-10. doi: 10.1056/NEJM197906213002502.
Autoantibodies that react exclusively with the gastrin-secreting cell of human antrum have been detected by immunofluorescence in eight of 106 patients with histologic evidence of chronic atrophic gastritis, Type B, involving mainly the antrum. These antibodies were of the IgG class and of low titer. However, follow-up studies one to two years later showed persistently positive reactions, despite symptomatic treatment. These data support the concept of an autoimmune variant of chronic "antral" gastritis, Type B.
通过免疫荧光法，在106例主要累及胃窦的B型慢性萎缩性胃炎组织学证据的患者中，有8例检测到仅与人胃窦促胃液素分泌细胞发生反应的自身抗体。这些抗体属于IgG类，滴度较低。然而，一到两年后的随访研究表明，尽管进行了对症治疗，但反应仍持续呈阳性。这些数据支持B型慢性“胃窦”胃炎自身免疫变体的概念。
