Liu Qi, Gao Yuan, He Jinzhi
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610041, China.
Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Biomedicines. 2023 Jul 20;11(7):2047. doi: 10.3390/biomedicines11072047.
Dental diseases occurring on young permanent teeth usually lead to the premature arrest of tooth root development. Sustained tooth root elongation is necessary to achieve the goal of long-term preservation of affected teeth. To this end, stem cell-based regenerative endodontic treatment has been regarded as one of the most promising strategies for treating young permanent teeth with pulp and periapical infections. Endogenous stem cells residing in the apical papilla, named stem cells from the apical papilla (SCAPs), have been intensively investigated due to their critical roles in pulp regeneration and root redevelopment. The present review summarizes advances in the field of SCAPs studies and discusses the challenges that need to be further addressed.
发生在年轻恒牙上的牙齿疾病通常会导致牙根发育过早停滞。持续的牙根伸长对于实现长期保存患牙的目标至关重要。为此，基于干细胞的再生牙髓治疗被认为是治疗患有牙髓和根尖感染的年轻恒牙最有前景的策略之一。位于根尖乳头的内源性干细胞，即根尖乳头干细胞（SCAPs），因其在牙髓再生和牙根再发育中的关键作用而受到深入研究。本综述总结了SCAPs研究领域的进展，并讨论了需要进一步解决的挑战。
