Chagneau Sophie, Gaucher Marie-Lou, Fravalo Philippe, Thériault William P, Thibodeau Alexandre
Research Chair in Meat Safety, Department of Pathology and Microbiology, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.
Swine and Poultry Infectious Diseases Research Center, Department of Pathology and Microbiology, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.
Microorganisms. 2023 Jun 28;11(7):1677. doi: 10.3390/microorganisms11071677.
is an important foodborne pathogen. Despite the lack of clinical signs associated with its colonization in poultry, it has been reported to interact with the intestinal immune system. However, little is known about the interaction between and the chicken immune system, especially in the context of hepatic dissemination. Therefore, to follow up on our previous study showing intestinal colonization and hepatic spread of , cecal tonsils and liver samples were collected from these birds to determine the mRNA levels of chemokines and cytokines. Serum samples were also collected to determine serum amyloid A (SAA) concentrations and specific IgY titers. Lack of Th17 induction was observed in the cecal tonsils of only the liver-contaminated groups. This hepatic dissemination was accompanied by innate, Th1 and Th2 immune responses in livers, as well as an increase in SAA concentrations and specific IgY levels in sera. appears to be able to restrain the induction of the chicken gut immunity in particular conditions, possibly enhancing its hepatic dissemination and thus eliciting systemic immune responses. Although is often recognized as a commensal-like bacterium in chickens, it seems to modulate the gut immune system and induce systemic immunity.
是一种重要的食源性病原体。尽管其在禽类中定植时缺乏相关临床症状，但据报道它会与肠道免疫系统相互作用。然而，关于它与鸡免疫系统之间的相互作用，尤其是在肝脏播散方面，人们了解甚少。因此，为了跟进我们之前显示其肠道定植和肝脏播散的研究，从这些禽类中采集盲肠扁桃体和肝脏样本，以确定趋化因子和细胞因子的mRNA水平。还采集了血清样本以测定血清淀粉样蛋白A（SAA）浓度和特异性IgY滴度。仅在肝脏受污染组的盲肠扁桃体中观察到缺乏Th17诱导。这种肝脏播散伴随着肝脏中的固有免疫、Th1和Th2免疫反应，以及血清中SAA浓度和特异性IgY水平的升高。在特定条件下似乎能够抑制鸡肠道免疫的诱导，可能会增强其肝脏播散从而引发全身免疫反应。尽管通常被认为是鸡体内类似共生菌的细菌，但它似乎会调节肠道免疫系统并诱导全身免疫。
