某物种的挥发性有机化合物：对其抗真菌特性的深入分析

The Volatile Organic Compounds of spp.: An In-Depth Analysis of Their Antifungal Properties.

作者信息

Cuervo Lorena, Álvarez-García Samuel, Salas José A, Méndez Carmen, Olano Carlos, Malmierca Mónica G

机构信息

Functional Biology Department, University of Oviedo, 33006 Oviedo, Spain.

University Institute of Oncology of Asturias (I.U.O.P.A), University of Oviedo, 33006 Oviedo, Spain.

出版信息

Microorganisms. 2023 Jul 16;11(7):1820. doi: 10.3390/microorganisms11071820.

The study of volatile organic compounds (VOCs) has expanded because of the growing need to search for new bioactive compounds that could be used as therapeutic alternatives. These small molecules serve as signals to establish interactions with other nearby organisms in the environment. In this work, we evaluated the antifungal effect of VOCs produced by different spp. This study was performed using VOC chamber devices that allow for the free exchange of VOCs without physical contact between microorganisms or the diffusible compounds they produce. Antifungal activity was tested against a fungal pathogen that affects ant nest stability, and the results showed that spp. CS014, CS057, CS131, CS147, CS159, CS207, and CS227 inhibit or reduce the fungal growth with their emitted VOCs. A GS-MS analysis of volatiles produced and captured by activated charcoal suggested that these strains synthesize several antifungal VOCs, many of them produced because of the presence of with the accumulation of various VOCs determining the growth inhibition effect.

由于寻找可作为治疗替代品的新型生物活性化合物的需求不断增长，挥发性有机化合物（VOCs）的研究得到了扩展。这些小分子作为信号，用于在环境中与其他附近的生物体建立相互作用。在这项工作中，我们评估了不同菌株产生的VOCs的抗真菌作用。本研究使用VOC腔室装置进行，该装置允许VOCs自由交换，而微生物或它们产生的可扩散化合物之间无需物理接触。针对一种影响蚁巢稳定性的真菌病原体测试了抗真菌活性，结果表明，CS014、CS057、CS131、CS147、CS159、CS207和CS227菌株通过其排放的VOCs抑制或减少了真菌生长。对活性炭产生和捕获的挥发物进行的气相色谱-质谱分析表明，这些菌株合成了几种抗真菌VOCs，其中许多是由于存在某种物质而产生的，各种VOCs的积累决定了生长抑制效果。