Department of Basic Medical Sciences, Catholic University of Valencia San Vicente Mártir, 46001 Valencia, Spain.
Doctoral School, Catholic University of Valencia San Vicente Mártir, 46001 Valencia, Spain.
Nutrients. 2023 Jul 24;15(14):3265. doi: 10.3390/nu15143265.
Autism Spectrum Disorder (ASD) is characterized by varying degrees of difficulty in social interaction and communication. These deficits are often associated with gastrointestinal symptoms, indicating alterations in both intestinal microbiota composition and metabolic activities. The intestinal microbiota influences the function and development of the nervous system. In individuals with ASD, there is an increase in bacterial genera such as , as well as species involved in the synthesis of branched-chain amino acids (BCAA) like . Conversely, decreased amounts of and spp. are observed. Epigallocatechin-3-gallate (EGCG) is one of the polyphenols with the greatest beneficial activity on microbial growth, and its consumption is associated with reduced psychological distress. Therefore, the objective of this review is to analyze how EGCG and its metabolites can improve the microbial dysbiosis present in ASD and its impact on the pathology. The analysis reveals that EGCG inhibits the growth of pathogenic bacteria like and . Moreover, it increases the abundance of spp. and spp. As a result, EGCG demonstrates efficacy in increasing the production of metabolites involved in maintaining epithelial integrity and improving brain function. This identifies EGCG as highly promising for complementary treatment in ASD.
自闭症谱系障碍（ASD）的特征是在社交互动和沟通方面存在不同程度的困难。这些缺陷通常与胃肠道症状有关，表明肠道微生物群落组成和代谢活动都发生了改变。肠道微生物群会影响神经系统的功能和发育。在 ASD 患者中，某些细菌属如 和参与支链氨基酸（BCAA）合成的物种如 的数量增加。相反， 和 spp. 的数量则减少。表没食子儿茶素没食子酸酯（EGCG）是对微生物生长具有最大有益活性的多酚之一，其摄入与降低心理困扰有关。因此，本综述的目的是分析 EGCG 及其代谢物如何改善 ASD 中存在的微生物失调及其对病理学的影响。分析表明，EGCG 抑制了像 这样的致病菌的生长。此外，它还增加了 spp. 和 spp. 的丰度。因此，EGCG 在增加参与维持上皮完整性和改善大脑功能的代谢物的产生方面具有功效。这表明 EGCG 非常有希望作为 ASD 的补充治疗方法。
