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伊朗多次输血患者血液病毒组特征。

Characterization of the Human Blood Virome in Iranian Multiple Transfused Patients.

机构信息

Laboratory for Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.

Department of Hematology, Faculty of Allied Medicine, Bushehr University of Medical Sciences, Bushehr 75146-33196, Iran.

出版信息

Viruses. 2023 Jun 23;15(7):1425. doi: 10.3390/v15071425.

DOI:10.3390/v15071425
PMID:37515113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10386462/
Abstract

Blood transfusion safety is an essential element of public health. Current blood screening strategies rely on targeted techniques that could miss unknown or unexpected pathogens. Recent studies have demonstrated the presence of a viral community (virobiota/virome) in the blood of healthy individuals. Here, we characterized the blood virome in patients frequently exposed to blood transfusion by using Illumina metagenomic sequencing. The virome of these patients was compared to viruses present in healthy blood donors. A total number of 155 beta-thalassemia, 149 hemodialysis, and 100 healthy blood donors were pooled with five samples per pool. Members of the and family were most frequently observed. Interestingly, samples of healthy blood donors harbored traces of potentially pathogenic viruses, including adeno-, rota-, and Merkel cell polyomavirus. Viruses of the family were most abundant in the blood of hemodialysis patients and displayed a higher anellovirus richness. Pegiviruses () were only observed in patient populations. An overall trend of higher eukaryotic read abundance in both patient groups was observed. This might be associated with increased exposure through blood transfusion. Overall, the findings in this study demonstrated the presence of various viruses in the blood of Iranian multiple-transfused patients and healthy blood donors.

摘要

输血安全是公共卫生的重要组成部分。目前的血液筛查策略依赖于靶向技术，可能会错过未知或意外的病原体。最近的研究表明，健康个体的血液中存在病毒群落（病毒组/病毒组）。在这里，我们通过使用 Illumina 宏基因组测序来描述经常接受输血的患者的血液病毒组。将这些患者的病毒组与健康献血者中的病毒进行比较。将 155 名β-地中海贫血患者、149 名血液透析患者和 100 名健康献血者的样本混合在一起，每个样本 5 个。 和 家族的成员最常被观察到。有趣的是，健康献血者的样本中存在潜在致病性病毒的痕迹，包括腺病毒、轮状病毒和 Merkel 细胞多瘤病毒。血液透析患者血液中的 家族病毒最为丰富，并且显示出更高的圆环病毒丰富度。 Pegivirus() 仅在患者群体中观察到。在两个患者组中均观察到真核生物读数丰度升高的总体趋势。这可能与通过输血增加暴露有关。总体而言，本研究的结果表明，伊朗多次输血患者和健康献血者的血液中存在多种病毒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/d2d608c79a45/viruses-15-01425-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/26886d7bb15f/viruses-15-01425-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/e0da67ebeaa9/viruses-15-01425-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/1e8b5cabd3cf/viruses-15-01425-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/3456f7861fb7/viruses-15-01425-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/1f0bef3b4c17/viruses-15-01425-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/fd61e099131d/viruses-15-01425-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/d2d608c79a45/viruses-15-01425-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/26886d7bb15f/viruses-15-01425-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/e0da67ebeaa9/viruses-15-01425-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/1e8b5cabd3cf/viruses-15-01425-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/3456f7861fb7/viruses-15-01425-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/1f0bef3b4c17/viruses-15-01425-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/fd61e099131d/viruses-15-01425-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/10386462/d2d608c79a45/viruses-15-01425-g007.jpg

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