Quarter-wise proportion and beta-lactam resistance rate of bovine mastitis associated- among infectious episodes in Ethiopia: Systematic review and meta-Analysis.

BACKGROUND

Bovine mastitis, a condition with multifactorial etiology, imposes a significant economic burden on the dairy sector in Ethiopia, with () being one of the leading etiologic agents. The acquisition of a compiled source of information concerning is imperative in order to enhance the control and prevention strategies, as well as to facilitate the successful implementation of the national action plan aimed at curbing antimicrobial resistance by the year 2025. Thus, the primary objective of this meta-analysis was to comprehensively summarize the estimates of the proportion and beta-lactam resistance profile of in bovine mastitis in Ethiopia.

METHODS

electronic bibliographic data such as PubMed, Web of Science, HINARI, Google Scholar, and other databases were used to search articles and quality assessment was performed using the AMSTAR-2. The pooled proportion, the rate of beta-lactam resistance, and a 95% confidence interval were calculated with a random effects model using statistical software. Funnel plots, and Eggers were used to assess publication bias.

RESULTS

Twenty-six (26) cross-sectional studies were included in this meta-analysis. The overall pooled proportion of was 35% (95% CI: 0.31 to 0.41). Considerable heterogeneity was observed in the included studies ( = 90.75%; P < 0.01). The subgroup analysis of the study region showed significant differences. The highest estimated regional pooled proportion of bovine mastitis-associated was 40% in the Amhara and Tigray regions. Funnel plot and Eggers results showed no statistically significant publication bias (Eggers test: p = 0.5656) in estimating the proportion of infections in association with bovine mastitis. A total of 14 articles were included to estimate beta-lactam antimicrobial resistance. The estimated pooled beta-lactam antimicrobial resistance rate of was resistance to penicillin at 75%, followed by amoxicillin at 67%, ampicillin at 50% and cephalosporin at 57% were evaluated in the treatment of . Therefore, the present meta-analysis has revealed that the prevalence of bovine-associated and its resistance to beta-lactam antibiotics are alarmingly high in the region of Ethiopia. This further emphasizes the vital necessity of implementing effective preventive measures to reduce the incidence and spread of this pathogen across the entire nation.