Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
Biomater Sci. 2023 Sep 12;11(18):6035-6059. doi: 10.1039/d3bm00544e.
Immune homeostasis is delicately mediated by the dynamic balance between effector immune cells and regulatory immune cells. Local deviations from immune homeostasis in the microenvironment of bone fractures, caused by an increased ratio of effector to regulatory cues, can lead to excessive inflammatory conditions and hinder bone regeneration. Therefore, achieving effective and localized immunomodulation of bone fractures is crucial for successful bone regeneration. Recent research has focused on developing localized and specific immunomodulatory strategies using local hydrogel-based delivery systems. In this review, we aim to emphasize the significant role of immune homeostasis in bone regeneration, explore local hydrogel-based delivery systems, discuss emerging trends in immunomodulation for enhancing bone regeneration, and address the limitations of current delivery strategies along with the challenges of clinical translation.
免疫稳态是由效应免疫细胞和调节免疫细胞之间的动态平衡精细调节的。骨折微环境中，由于效应信号与调节信号的比例增加，导致局部偏离免疫稳态，可能会导致过度炎症状态，阻碍骨再生。因此，实现骨折的有效和局部免疫调节对于成功的骨再生至关重要。最近的研究集中于使用局部水凝胶为基础的递药系统来开发有效的和局部特异性的免疫调节策略。在这篇综述中，我们旨在强调免疫稳态在骨再生中的重要作用，探讨基于局部水凝胶的递药系统，讨论免疫调节增强骨再生的新兴趋势，并解决当前递药策略的局限性以及临床转化的挑战。
