Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga, Mumbai, Maharashtra, 400019, India.
Eur J Drug Metab Pharmacokinet. 2023 Sep;48(5):495-514. doi: 10.1007/s13318-023-00843-7. Epub 2023 Jul 31.
Quercetin, a naturally occurring flavonoid, has been credited with a wide spectrum of therapeutic properties. However, the oral use of quercetin is limited due to its poor water solubility, low bioavailability, rapid metabolism, and rapid plasma clearance. Quercetin has been studied extensively when used with various nanodelivery systems for enhancing quercetin bioavailability. To enhance its oral bioavailability and efficacy, various quercetin-loaded nanosystems such as nanosuspensions, polymer nanoparticles, metal nanoparticles, emulsions, liposomes or phytosomes, micelles, solid lipid nanoparticles, and other lipid-based nanoparticles have been investigated in in-vitro cells, in-vivo animal models, and humans. Among the aforementioned nanosystems, quercetin phytosomes are attracting more interest and are available on the market. The present review covers insights into the possibilities of harnessing quercetin for several therapeutic applications and a special focus on anticancer applications and the clinical benefits of nanoquercetin formulations.
槲皮素是一种天然存在的类黄酮，具有广泛的治疗特性。然而，由于其水溶性差、生物利用度低、代谢快和血浆清除快，槲皮素的口服使用受到限制。槲皮素与各种纳米递药系统联合使用时已经进行了广泛的研究，以提高其生物利用度。为了提高其口服生物利用度和疗效，已经研究了各种负载有槲皮素的纳米系统，如纳米混悬剂、聚合物纳米粒、金属纳米粒、乳剂、脂质体或植物药、胶束、固体脂质纳米粒和其他基于脂质的纳米粒，这些系统在体外细胞、体内动物模型和人体中进行了研究。在上述纳米系统中，槲皮素植物药越来越受到关注，并已在市场上推出。本综述涵盖了利用槲皮素治疗多种疾病的可能性的见解，特别关注抗癌应用和纳米槲皮素制剂的临床益处。
