Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
J Med Virol. 2023 Aug;95(8):e28993. doi: 10.1002/jmv.28993.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is estimated to affect 0.4%-2.5% of the global population. Most cases are unexplained; however, some patients describe an antecedent viral infection or response to antiviral medications. We report here a multicenter study for the presence of viral nucleic acid in blood, feces, and saliva of patients with ME/CFS using polymerase chain reaction and high-throughput sequencing. We found no consistent group-specific differences other than a lower prevalence of anelloviruses in cases compared to healthy controls. Our findings suggest that future investigations into viral infections in ME/CFS should focus on adaptive immune responses rather than surveillance for viral gene products.
肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）估计影响全球 0.4%-2.5%的人口。大多数病例无法解释；然而，一些患者描述了先前的病毒感染或对抗病毒药物的反应。我们在此报告一项多中心研究，使用聚合酶链反应和高通量测序检测 ME/CFS 患者血液、粪便和唾液中的病毒核酸。除了与健康对照组相比，病例中无包膜病毒的患病率较低外，我们没有发现其他一致的组特异性差异。我们的研究结果表明，未来对 ME/CFS 中病毒感染的研究应侧重于适应性免疫反应，而不是病毒基因产物的监测。
