Opt Lett. 2023 Aug 1;48(15):3921-3924. doi: 10.1364/OL.492178.
This pilot study reports the development of optical coherence tomography (OCT) split-spectrum amplitude-decorrelation optoretinography (SSADOR) that measures spatially resolved photoreceptor response to light stimuli. Using spectrally multiplexed narrowband OCT, SSADOR improves sensitivity to microscopic changes without the need for cellular resolution or optical phase detection. Therefore, a large field of view (up to 3 × 1 mm demonstrated) using conventional OCT instrument design can be achieved, paving the way for clinical translation. SSADOR promises a fast, objective, and quantifiable functional biomarker for photoreceptor damage in the macula.
本初步研究报告了光学相干断层扫描（OCT）分谱振幅相关光感受器图（SSADOR）的开发，该方法可测量光刺激下空间分辨的光感受器反应。通过使用光谱复用的窄带 OCT，SSADOR 提高了对微观变化的敏感性，而无需细胞分辨率或光学相位检测。因此，可以使用传统的 OCT 仪器设计实现大视场（最多可达 3×1 毫米），为临床转化铺平了道路。SSADOR 有望成为黄斑区光感受器损伤的快速、客观和可量化的功能生物标志物。
