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用于烧伤治疗的抗氧化生物粘附凝胶的设计及其体外、体内评价

Design and in vitro, in vivo evaluation of antioxidant bioadhesive gels for burn treatment.

作者信息

Gökçe Göksel, Karavana Sinem Yaprak, Bağriyanik Alper, Pekçetin Çetin, Algin Yapar Evren, Aybar Tural Gülşen, Gökçe Evren Homan

机构信息

Department of Pharmacology, Faculty of Pharmacy, Ege University, Bornova, İzmir, Turkey.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, Bornova, İzmir, Turkey.

出版信息

Turk J Biol. 2022 Jan 17;46(3):251-262. doi: 10.55730/1300-0152.2613. eCollection 2022.

DOI:10.55730/1300-0152.2613
PMID:37529259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10388085/
Abstract

Burn wounds are frequently encountered health problems, which need a new treatment approach especially in terms of good patient compliance. Availability of use of antioxidant agents and bio-adhesive gels in tissue healing can be an alternative as a new approach for wound healing. Antioxidant taurine containing bio-adhesive gels were prepared by using carbopol (CP) 940 and 934. Rheological and texture analyses were carried out on bio-adhesive gels for in vitro characterization. Wound model on Wistar rats was used to evaluate the in vivo evaluation of gels. Rheological and texture analyses showed that a carbopol bioadhesive gel has acceptable topically use dosage characteristics and in combination with Taurine it presented a successful wound healing effect via antioxidant parameters. In conclusion, bio-adhesive CP 940 (2%) gel containing 50 mM taurine could be promising in the treatment of burns by balancing oxidative stress.

摘要

烧伤创面是常见的健康问题，尤其在患者依从性良好方面需要一种新的治疗方法。在组织愈合中使用抗氧化剂和生物粘附凝胶可以作为伤口愈合新方法的一种选择。通过使用卡波姆（CP）940和934制备了含抗氧化剂牛磺酸的生物粘附凝胶。对生物粘附凝胶进行流变学和质地分析以进行体外表征。使用Wistar大鼠的伤口模型来评估凝胶的体内效果。流变学和质地分析表明，卡波姆生物粘附凝胶具有可接受的局部使用剂量特性，并且与牛磺酸结合通过抗氧化参数呈现出成功的伤口愈合效果。总之，含有50 mM牛磺酸的生物粘附CP 940（2%）凝胶通过平衡氧化应激在烧伤治疗中可能具有前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/e6b63f72c98b/turkjbiol-46-3-251f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/4bc9b878ca98/turkjbiol-46-3-251f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/e077171c0005/turkjbiol-46-3-251f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/b6ac497f7465/turkjbiol-46-3-251f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/ef51d34efe66/turkjbiol-46-3-251f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/2cd496043f7d/turkjbiol-46-3-251f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/b7a3dbb8046b/turkjbiol-46-3-251f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/e6b63f72c98b/turkjbiol-46-3-251f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/4bc9b878ca98/turkjbiol-46-3-251f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/e077171c0005/turkjbiol-46-3-251f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/b6ac497f7465/turkjbiol-46-3-251f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/ef51d34efe66/turkjbiol-46-3-251f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/2cd496043f7d/turkjbiol-46-3-251f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/b7a3dbb8046b/turkjbiol-46-3-251f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/492f/10388085/e6b63f72c98b/turkjbiol-46-3-251f7.jpg

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