Lee Handule, Park Juyoung, Park Kwangsik
College of Pharmacy, Dongduk Women's University, Seoul 02748, Republic of Korea.
Toxics. 2023 Dec 4;11(12):986. doi: 10.3390/toxics11120986.
Bisphenol A (BPA) exposure has been widely linked to endocrine-disrupting effects. Recently, many substitutes for BPA have been developed as safe structural analogs. However, they have still been reported to have similar adverse effects. The current study evaluated the effects of bisphenol A and eight structural analogs on the transcription of estrogen receptor alpha (ERα). The effects of binary and ternary mixtures prepared from different combinations of BPA analogs were also evaluated for transcription activity. The measured data of the mixtures were compared to the predicted data obtained by the full logistic model, and the model deviation ratio (MDR) was calculated to determine whether the effects were synergistic, antagonistic, or additive. Overall, the results suggest that the effect of bisphenol compound are additive in binary and ternary mixtures.
双酚A（BPA）暴露已被广泛认为与内分泌干扰效应有关。最近，许多双酚A的替代品已被开发为安全的结构类似物。然而，仍有报道称它们具有类似的不良影响。本研究评估了双酚A及其八种结构类似物对雌激素受体α（ERα）转录的影响。还评估了由双酚A类似物的不同组合制备的二元和三元混合物对转录活性的影响。将混合物的实测数据与通过完全逻辑模型获得的预测数据进行比较，并计算模型偏差率（MDR）以确定这些效应是协同的、拮抗的还是相加的。总体而言，结果表明双酚化合物在二元和三元混合物中的效应是相加的。
