Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, Oakland.
Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania.
JAMA Netw Open. 2023 Aug 1;6(8):e2327138. doi: 10.1001/jamanetworkopen.2023.27138.
Research has found associations of pregnancy-specific alcohol policies with increased low birth weight and preterm birth, but associations with other infant outcomes are unknown.
To examine the associations of pregnancy-specific alcohol policies with infant morbidities and maltreatment.
DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study used outcome data from Merative MarketScan, a national database of private insurance claims. The study cohort included individuals aged 25 to 50 years who gave birth to a singleton between 2006 and 2019 in the US, had been enrolled 1 year before and 1 year after delivery, and could be matched with an infant. Data were analyzed from August 2021 to April 2023.
Nine state-level pregnancy-specific alcohol policies obtained from the National Institute on Alcohol Abuse and Alcoholism's Alcohol Policy Information System.
The primary outcomes were 1 or more infant injuries associated with maltreatment and infant morbidities associated with maternal alcohol consumption within the first year. Logistic regression, adjusting for individual-level and state-level controls, and fixed effects for state, year, state-specific time trends, and SEs clustered by state were used.
A total of 1 432 979 birthing person-infant pairs were included (mean [SD] age of birthing people, 32.2 [4.2] years); 30 157 infants (2.1%) had injuries associated with maltreatment, and 44 461 (3.1%) infants had morbidities associated with alcohol use during pregnancy. The policies of Reporting Requirements for Assessment/Treatment (adjusted odds ratio [aOR], 1.28; 95% CI, 1.08-1.52) and Mandatory Warning Signs (aOR, 1.18; 95% CI, 1.10-1.27) were associated with increased odds of infant injuries but not morbidities. Priority Treatment for Pregnant Women Only was associated with decreased odds of infant injuries (aOR, 0.83; 95% CI, 0.76-0.90) but not infant morbidities. Civil Commitment was associated with increased odds of infant injuries (aOR, 1.26; 95% CI, 1.08-1.48) but decreased odds of infant morbidities (aOR, 0.57; 95% CI, 0.53-0.62). Priority Treatment for Pregnant Women and Women With Children was associated with increased odds of both infant injuries (aOR, 1.12; 95% CI, 1.00-1.25) and infant morbidities (aOR, 1.08; 95% CI, 1.03-1.13). Reporting Requirements for Child Protective Services, Reporting Requirements for Data, Child Abuse/Neglect, and Limits on Criminal Prosecution were not associated with infant injuries or morbidities.
In this cohort study, most pregnancy-specific alcohol policies were not associated with decreased odds of infant injuries or morbidities. Policy makers should not assume that pregnancy-specific alcohol policies improve infant health.
研究发现,特定于妊娠的酒精政策与低出生体重和早产增加有关,但与其他婴儿结局的关联尚不清楚。
研究特定于妊娠的酒精政策与婴儿发病和虐待的关联。
设计、地点和参与者:这是一项回顾性队列研究,使用了 Merative MarketScan 的结果数据,这是一个私人保险索赔的国家数据库。研究队列包括 2006 年至 2019 年在美国分娩的年龄在 25 至 50 岁之间的个体,在分娩前和分娩后 1 年都参加了该研究,并可以与婴儿匹配。数据分析于 2021 年 8 月至 2023 年 4 月进行。
从国家酒精滥用和酒精中毒研究所的酒精政策信息系统获得的 9 项州级特定于妊娠的酒精政策。
主要结果是在婴儿出生后的第一年,与虐待有关的 1 次或多次婴儿受伤和与母亲饮酒有关的婴儿发病。使用逻辑回归,调整个体和州级控制,以及州、年、州特定时间趋势的固定效应和按州聚类的标准误差。
共纳入 1432979 名分娩者-婴儿对(分娩者的平均[SD]年龄为 32.2[4.2]岁);30157 名婴儿(2.1%)有与虐待有关的受伤,44461 名婴儿(3.1%)有与怀孕期间饮酒有关的发病。报告要求评估/治疗(调整后的优势比[OR],1.28;95%CI,1.08-1.52)和强制性警示标志(OR,1.18;95%CI,1.10-1.27)政策与婴儿受伤的几率增加有关,但与发病无关。仅为孕妇提供优先治疗(OR,0.83;95%CI,0.76-0.90)与婴儿受伤的几率降低有关,但与发病无关。强制住院(OR,1.26;95%CI,1.08-1.48)与婴儿受伤的几率增加有关,但与婴儿发病的几率降低(OR,0.57;95%CI,0.53-0.62)有关。仅为孕妇和有子女的妇女提供优先治疗(OR,1.12;95%CI,1.00-1.25)与婴儿受伤(OR,1.08;95%CI,1.03-1.13)和发病的几率增加有关。儿童保护服务报告要求、数据报告要求、儿童虐待/忽视和刑事起诉限制与婴儿受伤或发病无关。
在这项队列研究中,大多数特定于妊娠的酒精政策与婴儿受伤或发病几率的降低无关。政策制定者不应假设特定于妊娠的酒精政策能改善婴儿健康。