Klinkhoff A V, Beattie C W, Chalmers A
Arthritis Rheum. 1986 Sep;29(9):1152-6. doi: 10.1002/art.1780290914.
Forty-three patients taking chloroquine for systemic lupus erythematosus were followed by one ophthalmologist over a 5-year period. Visual field testing, color vision testing, and fluorescein angiography were performed. Retinopathy was detected in 7 patients (16%), none of whom had hypertension or diabetes mellitus. Retinal abnormalities included cotton-wool spots in 4 patients, microaneurysms in 3, and vascular tortuosity in 4. In 4 patients, these abnormalities were associated with retinal dysfunction, measured in terms of abnormal hue discrimination. In 6 of the 7 patients, the finding of retinopathy coincided with a flare of lupus activity. In 5 patients, retinopathy improved when the disease was controlled.
一位眼科医生对43名因系统性红斑狼疮而服用氯喹的患者进行了为期5年的随访。进行了视野测试、色觉测试和荧光素血管造影。在7名患者（16%）中检测到视网膜病变，这些患者均无高血压或糖尿病。视网膜异常包括4名患者出现棉絮斑，3名患者出现微动脉瘤，4名患者出现血管迂曲。在4名患者中，这些异常与以异常色调辨别衡量的视网膜功能障碍有关。在7名患者中的6名中，视网膜病变的发现与狼疮活动的发作同时出现。在5名患者中，病情得到控制时视网膜病变有所改善。
