Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang, Department of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital, Cancer Center, Zhejiang University School of Medicine, Hangzhou, China.
Front Immunol. 2023 Jul 21;14:1225948. doi: 10.3389/fimmu.2023.1225948. eCollection 2023.
The tumor microenvironment (TME) is a crucial driving factor for tumor progression and it can hinder the body's immune response by altering the metabolic activity of immune cells. Both tumor and immune cells maintain their proliferative characteristics and physiological functions through transporter-mediated regulation of nutrient acquisition and metabolite efflux. Transporters also play an important role in modulating immune responses in the TME. In this review, we outline the metabolic characteristics of the TME and systematically elaborate on the effects of abundant metabolites on immune cell function and transporter expression. We also discuss the mechanism of tumor immune escape due to transporter dysfunction. Finally, we introduce some transporter-targeted antitumor therapeutic strategies, with the aim of providing new insights into the development of antitumor drugs and rational drug usage for clinical cancer therapy.
肿瘤微环境（TME）是肿瘤进展的关键驱动因素，它可以通过改变免疫细胞的代谢活性来阻碍机体的免疫反应。肿瘤细胞和免疫细胞通过转运体介导的营养物质摄取和代谢产物外排来调节，从而维持其增殖特性和生理功能。转运体在调节 TME 中的免疫反应方面也起着重要作用。在这篇综述中，我们概述了 TME 的代谢特征，并系统地阐述了丰富的代谢产物对免疫细胞功能和转运体表达的影响。我们还讨论了由于转运体功能障碍导致的肿瘤免疫逃逸机制。最后，我们介绍了一些针对转运体的抗肿瘤治疗策略，以期为抗肿瘤药物的开发和临床癌症治疗的合理用药提供新的思路。
