Medical Technology College, Xuzhou Medical University, Xuzhou, China.
Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore.
ISME J. 2023 Oct;17(10):1733-1740. doi: 10.1038/s41396-023-01478-x. Epub 2023 Aug 7.
Recent studies have shown that gut microorganisms can modulate host lifespan and activities, including sleep quality and motor performance. However, the role of gut microbial genetic variation in regulating host phenotypes remains unclear. In this study, we investigated the links between gut microbial genetic variation and host phenotypes using Saccharomyces cerevisiae and Drosophila melanogaster as research models. Our result suggested a novel role for peroxisome-related genes in yeast in regulating host lifespan and activities by modulating gut oxidative stress. Specifically, we found that deficiency in catalase A (CTA1) in yeast reduced both the sleep duration and lifespan of fruit flies significantly. Furthermore, our research also expanded our understanding of the relationship between sleep and longevity. Using a large sample size and excluding individual genetic background differences, we found that lifespan is associated with sleep duration, but not sleep fragmentation or motor performance. Overall, our study provides novel insights into the role of gut microbial genetic variation in regulating host phenotypes and offers potential new avenues for improving health and longevity.
最近的研究表明，肠道微生物可以调节宿主的寿命和活动，包括睡眠质量和运动性能。然而，肠道微生物遗传变异在调节宿主表型中的作用尚不清楚。在这项研究中，我们使用酿酒酵母和黑腹果蝇作为研究模型，研究了肠道微生物遗传变异与宿主表型之间的联系。我们的结果表明，过氧化物酶体相关基因在酵母中通过调节肠道氧化应激来调节宿主寿命和活动方面发挥着新的作用。具体来说，我们发现酵母中过氧化氢酶 A（CTA1）的缺乏显著降低了果蝇的睡眠时间和寿命。此外，我们的研究还扩展了我们对睡眠与长寿之间关系的理解。使用大样本量并排除个体遗传背景差异，我们发现寿命与睡眠时间有关，但与睡眠片段化或运动性能无关。总的来说，我们的研究为肠道微生物遗传变异在调节宿主表型中的作用提供了新的见解，并为改善健康和长寿提供了潜在的新途径。
