Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Nutrients. 2019 Mar 15;11(3):636. doi: 10.3390/nu11030636.
Inulin is considered an efficient prebiotic and is beneficial for metabolic diseases via promoting intestinal probiotic enrichment and the metabolites of short-chain fatty acids (SCFAs). However, the effect of inulin on patients with deficiencies has seldom been reported. In this study, the lifespan, related gene expression, and gut microbiota of /TM3 (insulin receptor mutant) under inulin treatment were investigated. The results showed that the lifespan was extended in only males and not in females. Furthermore, distinctly different patterns of gene expression were found between males and females, especially in the insulin/insulin-like growth factor (IGF)-like signalling (IIS) and target of rapamycin (TOR) pathways. Additionally, as a link between inulin and lifespan responses, the gut microbiota was distinctly separated by gender in both the standard diet group and the inulin treatment group, and the relationship between lifespan and the gut microbiota community was stronger in male flies than in females. This study provides preliminary evidence for the gender-dependent lifespan responses to inulin in insulin signalling-deficient . However, controls such as wild-type and TM3 flies, and more mutant strains with different genetic backgrounds need to be further investigated to elucidate the mechanisms underlying the phenomenon.
菊粉被认为是一种有效的益生元，通过促进肠道益生菌的富集和短链脂肪酸（SCFAs）的代谢物，对代谢疾病有益。然而，菊粉对缺乏症患者的影响很少有报道。在这项研究中，研究了在菊粉处理下 /TM3（胰岛素受体突变体）的寿命、相关基因表达和肠道微生物群。结果表明，只有雄性而不是雌性的寿命延长。此外，雄性和雌性之间发现了明显不同的基因表达模式，特别是在胰岛素/胰岛素样生长因子（IGF）样信号（IIS）和雷帕霉素靶蛋白（TOR）途径中。此外，作为菊粉和寿命反应之间的联系，肠道微生物群在标准饮食组和菊粉处理组中都明显按性别分离，并且寿命与肠道微生物群落之间的关系在雄性果蝇中比在雌性果蝇中更强。这项研究为胰岛素信号缺陷缺乏症中菊粉对寿命的性别依赖性反应提供了初步证据。然而，需要进一步研究野生型和 TM3 果蝇等对照，以及具有不同遗传背景的更多 突变株，以阐明这种现象的机制。
