一种在复制周期后期起作用的流感病毒抑制剂。

An influenza virus inhibitor that acts late in the replication cycle.

作者信息

Antonelli G, Dianzani F, Coppenhaver D H, Baron S, Calandra P, Folchitto G

出版信息

Antimicrob Agents Chemother. 1986 Jan;29(1):49-51. doi: 10.1128/AAC.29.1.49.

DOI:10.1128/AAC.29.1.49

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC180362/

Abstract

An inhibitor which is active against influenza A virus was found in Neuramide, a complex tissue extract that is used as an anti-herpes zoster virus treatment. Kinetic studies showed that significant inhibition of virus production occurred when the inhibitor was added to infected cultures up to 5 h after virus penetration. Molecular sieving fractionation showed that the antiviral activity was contained in a low-molecular-weight fraction (molecular weight, less than 1,000).

摘要

在神经酰胺中发现了一种对甲型流感病毒有活性的抑制剂，神经酰胺是一种复杂的组织提取物，用作抗带状疱疹病毒的治疗药物。动力学研究表明，在病毒侵入后长达5小时向受感染培养物中添加该抑制剂时，病毒产生受到显著抑制。分子筛分级分离表明，抗病毒活性存在于低分子量级分（分子量小于1000）中。

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本文引用的文献

1

Non-interferon cellular products capable of virus inhibition.具有病毒抑制能力的非干扰素细胞产物。

Tex Rep Biol Med. 1981;41:395-401.

2

Size and stability of a naturally occurring virus inhibitor.一种天然存在的病毒抑制剂的大小与稳定性。

Antimicrob Agents Chemother. 1984 May;25(5):646-9. doi: 10.1128/AAC.25.5.646.

3

A broadly active viral inhibitor in human and animal organ extracts and body fluids.一种在人和动物器官提取物及体液中具有广泛活性的病毒抑制剂。

Proc Soc Exp Biol Med. 1984 Oct;177(1):104-11. doi: 10.3181/00379727-177-41918.

4

[An inhibitor of the replication of varicella-zoster virus].[一种水痘带状疱疹病毒复制的抑制剂]

G Ital Chemioter. 1980 Jul-Dec;27(2):103-6.

5

Broadly active inhibitor of viruses spontaneously produced by many cell types in culture.对培养中多种细胞类型自发产生的病毒具有广泛活性的抑制剂。

Infect Immun. 1981 May;32(2):449-53. doi: 10.1128/iai.32.2.449-453.1981.

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