Antonelli G, Dianzani F, Coppenhaver D H, Baron S, Calandra P, Folchitto G
Antimicrob Agents Chemother. 1986 Jan;29(1):49-51. doi: 10.1128/AAC.29.1.49.
An inhibitor which is active against influenza A virus was found in Neuramide, a complex tissue extract that is used as an anti-herpes zoster virus treatment. Kinetic studies showed that significant inhibition of virus production occurred when the inhibitor was added to infected cultures up to 5 h after virus penetration. Molecular sieving fractionation showed that the antiviral activity was contained in a low-molecular-weight fraction (molecular weight, less than 1,000).
在神经酰胺中发现了一种对甲型流感病毒有活性的抑制剂，神经酰胺是一种复杂的组织提取物，用作抗带状疱疹病毒的治疗药物。动力学研究表明，在病毒侵入后长达5小时向受感染培养物中添加该抑制剂时，病毒产生受到显著抑制。分子筛分级分离表明，抗病毒活性存在于低分子量级分（分子量小于1000）中。
