Coppenhaver D H, Baron J L, McKerlie M L, Sabados J, Baron S
Antimicrob Agents Chemother. 1984 May;25(5):646-9. doi: 10.1128/AAC.25.5.646.
We recently described a virus inhibitor (contact-blocking virus inhibitor) which was produced spontaneously by untransformed human and murine cells in tissue culture (S. Baron and L. McKerlie , Infect. Immun . 32:449-453, 1981). This contact-blocking virus inhibitor was characterized by broad antiviral activity, high potency, and reversible inhibition of viral attachment. Unlike interferon, the antiviral activity of the contact-blocking virus inhibitor is not species specific. An inhibitor with similar properties can also be demonstrated in many body fluids and surface secretions. We report here studies on the stability of the antiviral species which indicate that it is resistant to denaturation by heat (100 degrees C), acid (pH 2), and alkali (pH 12). The antiviral activity against all viruses tested resides in a low-molecular-weight molecule. The range of characteristics so far determined for the contact-blocking virus inhibitor distinguishes it from other virus inhibitors reported in the literature.
我们最近描述了一种病毒抑制剂（接触阻断型病毒抑制剂），它是由未转化的人源和鼠源细胞在组织培养中自发产生的（S. 巴伦和L. 麦柯利，《感染与免疫》32:449 - 453，1981年）。这种接触阻断型病毒抑制剂具有广泛的抗病毒活性、高效力以及对病毒附着的可逆性抑制作用。与干扰素不同，接触阻断型病毒抑制剂的抗病毒活性没有种属特异性。在许多体液和体表分泌物中也能证明存在具有类似性质的抑制剂。我们在此报告对抗病毒物质稳定性的研究，结果表明它对热（100摄氏度）、酸（pH 2）和碱（pH 12）的变性作用具有抗性。针对所有测试病毒的抗病毒活性存在于一种低分子量分子中。到目前为止所确定的接触阻断型病毒抑制剂的一系列特性使其有别于文献中报道的其他病毒抑制剂。
