Chowdhry Aman, Kapoor Priyanka, Bhargava Deepak, Bagga Dinesh Kumar
School of Dental Sciences, Sharda University, Greater Noida (UP), India.
Department of Oral Pathology & Microbiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India.
Discoveries (Craiova). 2023 Jun 30;11(2):e165. doi: 10.15190/d.2023.4. eCollection 2023 Apr-Jun.
The oral cavity is home to diverse microbial content, collectively called as the oral microbiome. The latest technological advancements have unraveled the intricacies of the oral microbiome. It can be of great importance for oral health care givers to know the fundamentals and latest developments in the field of the oral microbiome, as oral dysbiosis is associated with many common diseases frequently seen and managed by them. These diseases include dental caries, periodontitis, mucosal diseases (such as oral leukoplakia, oral lichen planus, and systemic lupus erythematosus), oral cancers, and even co-infections related to the current COVID-19 pandemic. The emergence of new genomic and molecular biology methodologies has been pivotal for understanding the role of the human microbiome in health and disease. The current review compiles oral microbiome in health and disease with a multidisciplinary dental approach. The insight into the oral microbiome, which is provided dental specialty wise in the current article will initiate and guide researchers of various disciplines in developing microbiome-based therapeutic or prophylactic management strategies, managing public health challenges by microbiome-based boarder interventions and divert resources for preserving and achieving a balanced oral microbiome.
口腔是多种微生物的栖息地，这些微生物统称为口腔微生物群。最新的技术进步揭示了口腔微生物群的复杂性。对于口腔保健人员来说，了解口腔微生物群领域的基础知识和最新进展非常重要，因为口腔生态失调与他们经常见到和处理的许多常见疾病有关。这些疾病包括龋齿、牙周炎、黏膜疾病（如口腔白斑、口腔扁平苔藓和系统性红斑狼疮）、口腔癌，甚至与当前新冠疫情相关的合并感染。新的基因组学和分子生物学方法的出现对于理解人类微生物群在健康和疾病中的作用至关重要。本综述采用多学科牙科方法汇编了健康和疾病中的口腔微生物群。本文按牙科专业提供的对口腔微生物群的见解，将启动并指导各学科的研究人员制定基于微生物群的治疗或预防管理策略，通过基于微生物群的更广泛干预应对公共卫生挑战，并为保护和实现平衡的口腔微生物群分配资源。
