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儿童酒渣鼻:综述。

Rosacea in children: a review.

机构信息

Department of Dermatology, Nicolina Medical Center, Iasi, Romania.

Apollonia University, Iasi, Romania.

出版信息

Eur J Pediatr. 2023 Oct;182(10):4323-4328. doi: 10.1007/s00431-023-05083-0. Epub 2023 Aug 9.

DOI:10.1007/s00431-023-05083-0
PMID:37555972
Abstract

UNLABELLED

Rosacea is a facial inflammatory disorder that shows an increasing incidence with age. While rosacea is common > 60 years of age, pediatric rosacea is uncommon. Diagnostic criteria are based on clinical symptoms. Laboratory investigations and histopathology are only needed to exclude other differential diagnoses. There are several subtypes such as erythemato-telangiectatic, papulo-pustular, periorificial, and granulomatous variants. In contrast to adult rosacea, phymatous subtypes do not belong to pediatric rosacea. A special subtype seen in infants and children is an idiopathic facial aseptic granuloma. Genetic and environmental factors contribute to its pathogenesis. Treatment options are in analogy to adult rosacea classified into topical and systemic drugs. In the case of oral tetracyclines, discoloration of teeth and impairment of enamel are possible adverse events.

CONCLUSION

Pediatric rosacea belongs to the rosacea spectrum but has peculiarities compared to the adult subtype.

WHAT IS KNOWN

• Rosacea is a chronic inflammatory disorder different from acne. • Rosacea gets more common with advanced age.

WHAT IS NEW

• Pediatric rosacea is an uncommon subtype with peculiar clinical presentation. • Demodicosis is very rare in immunocompetent children.

摘要

未标注

酒渣鼻是一种面部炎症性疾病,其发病率随年龄增长而增加。虽然酒渣鼻在>60 岁的人群中很常见,但儿童酒渣鼻并不常见。诊断标准基于临床症状。只有为排除其他鉴别诊断才需要进行实验室检查和组织病理学检查。有几种亚型,如红斑毛细血管扩张型、丘疹脓疱型、眶周型和肉芽肿型。与成人酒渣鼻不同,鼻赘型不属于儿童酒渣鼻。婴儿和儿童中可见一种特发性面部无菌性肉芽肿,是一种特殊的亚型。遗传和环境因素促成其发病机制。治疗选择与成人酒渣鼻类似,分为局部和全身药物。口服四环素可能会出现牙齿变色和牙釉质损伤等不良反应。

结论

儿童酒渣鼻属于酒渣鼻谱系,但与成人亚型有其特殊性。

已知内容

• 酒渣鼻是一种不同于痤疮的慢性炎症性疾病。

• 随着年龄的增长,酒渣鼻的发病率越来越高。

新内容

• 儿童酒渣鼻是一种少见的亚型,具有独特的临床表现。

• 免疫功能正常的儿童中非常罕见蠕形螨病。

相似文献

1
Rosacea in children: a review.儿童酒渣鼻:综述。
Eur J Pediatr. 2023 Oct;182(10):4323-4328. doi: 10.1007/s00431-023-05083-0. Epub 2023 Aug 9.
2
Childhood rosacea and related disorders.儿童酒渣鼻及相关疾病。
Clin Exp Dermatol. 2021 Apr;46(3):430-437. doi: 10.1111/ced.14419. Epub 2020 Nov 20.
3
Should idiopathic facial aseptic granuloma be considered granulomatous rosacea? Report of three pediatric cases.特发性面部无菌性肉芽肿应被视为肉芽肿性酒渣鼻吗?三例儿科病例报告。
Pediatr Dermatol. 2013 Jan-Feb;30(1):109-11. doi: 10.1111/j.1525-1470.2011.01689.x. Epub 2012 Feb 16.
4
Granulomatous rosacea in infants. Report of three cases and discussion of the differential diagnosis.婴儿肉芽肿性酒渣鼻。三例报告及鉴别诊断讨论。
Dermatol Online J. 2008 Feb 28;14(2):22.
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Idiopathic facial aseptic granuloma-A diagnostic challenge in pediatric dermatology.特发性面部无菌性肉芽肿——儿科皮肤病学中的诊断难题
Pediatr Dermatol. 2018 Jul;35(4):490-493. doi: 10.1111/pde.13492. Epub 2018 Apr 6.
6
Idiopathic aseptic facial granuloma: A retrospective study of 43 cases.特发性无菌性面部肉芽肿:43 例回顾性研究。
Pediatr Dermatol. 2024 Mar-Apr;41(2):243-246. doi: 10.1111/pde.15571. Epub 2024 Feb 27.
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Treatment of aseptic facial granuloma as a manifestation of pediatric rosacea with oral macrolides.以口服大环内酯类药物治疗无菌性面部肉芽肿作为儿童酒渣鼻的一种表现。
Pediatr Dermatol. 2023 Nov-Dec;40(6):1064-1067. doi: 10.1111/pde.15420. Epub 2023 Sep 5.
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Rosacea and rhinophyma.酒渣鼻和鼻赘。
Clin Dermatol. 2014 Jan-Feb;32(1):35-46. doi: 10.1016/j.clindermatol.2013.05.024.
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Clinical presentations and classification of rosacea.酒渣鼻的临床表现与分类。
Ann Dermatol Venereol. 2011 Nov;138 Suppl 3:S192-200. doi: 10.1016/S0151-9638(11)70089-8.
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Rosacea management: A comprehensive review.酒渣鼻管理:全面综述。
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Periorificial dermatitis in infants and preschoolers - a narrative review.婴幼儿口周皮炎——一篇综述
Eur J Pediatr. 2025 Jan 17;184(2):143. doi: 10.1007/s00431-025-05975-3.
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A Novel Monoallelic Small Deletion Confers Gain-of-Function of STAT1 in a Child with Candidiasis and Mycobacterial Diseases.一种新型单等位基因小缺失赋予一名患念珠菌病和分枝杆菌病儿童的信号转导和转录激活因子1(STAT1)功能获得性改变。

本文引用的文献

1
Role of the skin microbiota and intestinal microbiome in rosacea.皮肤微生物群和肠道微生物组在玫瑰痤疮中的作用。
Front Microbiol. 2023 Feb 10;14:1108661. doi: 10.3389/fmicb.2023.1108661. eCollection 2023.
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The temperature-sensitive receptors TRPV4 and TRPM8 have important roles in the pruritus of rosacea.温度敏感性受体 TRPV4 和 TRPM8 在酒渣鼻瘙痒中具有重要作用。
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Risk of Dental Discoloration and Enamel Dysplasia in Children Exposed to Tetracycline and Its Derivatives.
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Plant Phenolics in the Prevention and Therapy of Acne: A Comprehensive Review.植物多酚在痤疮的预防和治疗中的作用:综述
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Association between rosacea and helicobacter pylori infection: A meta-analysis.玫瑰痤疮与幽门螺杆菌感染的相关性:一项荟萃分析。
PLoS One. 2024 Apr 4;19(4):e0301703. doi: 10.1371/journal.pone.0301703. eCollection 2024.
儿童暴露于四环素及其衍生物中牙齿变色和釉质发育不全的风险。
Yonsei Med J. 2022 Dec;63(12):1113-1120. doi: 10.3349/ymj.2022.0388.
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Idiopathic facial aseptic granuloma: Report of successful treatment with low-dose isotretinoin in a pediatric patient with trisomy 21.特发性面部无菌性肉芽肿:低剂量异维A酸成功治疗1例21三体综合征患儿的报告。
JAAD Case Rep. 2022 May 2;24:88-90. doi: 10.1016/j.jdcr.2022.04.018. eCollection 2022 Jun.
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Rosacea: New Concepts in Classification and Treatment.酒渣鼻:分类和治疗的新概念。
Am J Clin Dermatol. 2021 Jul;22(4):457-465. doi: 10.1007/s40257-021-00595-7. Epub 2021 Mar 23.
6
Childhood rosacea and related disorders.儿童酒渣鼻及相关疾病。
Clin Exp Dermatol. 2021 Apr;46(3):430-437. doi: 10.1111/ced.14419. Epub 2020 Nov 20.
7
Topical calcineurin inhibitors for pediatric periorificial dermatitis.用于儿童口周皮炎的外用钙调神经磷酸酶抑制剂
J Am Acad Dermatol. 2020 Jun;82(6):1409-1414. doi: 10.1016/j.jaad.2020.01.064. Epub 2020 Feb 4.
8
Rosacea as a striking feature in family members with a STAT1 gain-of-function mutation.酒渣鼻是具有STAT1功能获得性突变的家庭成员的一个显著特征。
J Eur Acad Dermatol Venereol. 2020 Jun;34(6):e265-e267. doi: 10.1111/jdv.16241. Epub 2020 Feb 27.
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Dermoscopy of idiopathic facial aseptic granuloma.特发性面部无菌性肉芽肿的皮肤镜检查
Clin Exp Dermatol. 2020 Jul;45(5):605-606. doi: 10.1111/ced.14174. Epub 2020 Feb 3.
10
The Role of IL-17 in Papulopustular Rosacea and Future Directions.白细胞介素-17在丘疹脓疱型酒渣鼻中的作用及未来方向
J Cutan Med Surg. 2019 Nov/Dec;23(6):635-641. doi: 10.1177/1203475419867611. Epub 2019 Aug 12.