Bhandari Sagar, Yadav Vikas, Ishaq Aqsa, Sanipini Sailakshmn, Ekhator Chukwuyem, Khleif Rafeef, Beheshtaein Alee, Jhajj Loveleen K, Khan Aimen Waqar, Al Khalifa Ahmed, Naseem Muhammad Arsal, Bellegarde Sophia B, Nadeem Muhammad A
Cardiology, Tucson Medical Center, Tucson, USA.
Internal Medicine, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, IND.
Cureus. 2023 Aug 9;15(8):e43204. doi: 10.7759/cureus.43204. eCollection 2023 Aug.
This article provides a comprehensive review of the current trends and challenges in the development of 3D-printed heart valves and other cardiac implants. By providing personalized solutions and pushing the limits of regenerative medicine, 3D printing technology has revolutionized the field of cardiac healthcare. The use of several organic and synthetic polymers in 3D printing heart valves is explored in this article, with emphasis on both their benefits and drawbacks. In cardiac tissue engineering, stem cells are essential, and their potential to lessen immunological rejection and thrombogenic consequences is highlighted. In the clinical applications section, the article emphasizes the importance of 3D printing in preoperative planning. Surgery results are enhanced when surgeons can visualize and assess the size and placement of implants using patient-specific anatomical models. Customized implants that are designed to match the anatomy of a particular patient reduce the likelihood of complications and enhance postoperative results. The development of physiologically active cardiac implants, made possible by 3D bioprinting, shows promise by eliminating the need for artificial valves. In conclusion, this paper highlights cutting-edge research and the promise of 3D-printed cardiac implants to improve patient outcomes and revolutionize cardiac treatment.
本文全面综述了3D打印心脏瓣膜及其他心脏植入物发展的当前趋势与挑战。通过提供个性化解决方案并突破再生医学的极限，3D打印技术彻底改变了心脏医疗领域。本文探讨了在3D打印心脏瓣膜中使用的几种有机和合成聚合物，重点介绍了它们的优点和缺点。在心脏组织工程中，干细胞至关重要，文中强调了其减轻免疫排斥和血栓形成后果的潜力。在临床应用部分，本文强调了3D打印在术前规划中的重要性。当外科医生能够使用患者特异性解剖模型可视化并评估植入物的大小和位置时，手术效果会得到改善。定制的植入物旨在匹配特定患者的解剖结构，可降低并发症的可能性并提高术后效果。通过3D生物打印实现的生理活性心脏植入物的开发，有望消除对人工瓣膜的需求。总之，本文突出了前沿研究以及3D打印心脏植入物改善患者预后并彻底改变心脏治疗的前景。
