Oh Hyun-Ji, Jin Heegu, Lee Boo-Yong
Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam 13488, Gyeonggi, Republic of Korea.
Cells. 2023 Aug 7;12(15):2015. doi: 10.3390/cells12152015.
Faced with a globally aging society, the maintenance of health and quality of life in older people is very important. The age-related loss of muscle mass and strength, known as sarcopenia, severely reduces quality of life and increases the risks of various diseases. In this study, we investigated the inhibitory effect of hesperidin (HES) on inflammaging, with the intention of evaluating its potential use as a treatment for sarcopenia. We studied 22-26-month-old mice, corresponding to humans aged ≥70 years, with aging-related sarcopenia, and young mice aged 3-6 months. The daily administration of HES for 8 weeks resulted in greater muscle mass and strength and increased the fiber size of the old mice. HES also restored the immune homeostasis that had been disrupted by aging, such as the imbalance in M1/M2 macrophage ratio. In addition, we found that HES ameliorated the sarcopenia by regulating AKT/mammalian target of rapamycin/forkhead box 3a signaling through an increase in insulin-like growth factor (IGF)-1 expression in the old mice. Therefore, HES represents a promising candidate inhibitor of sarcopenia in older people, and its effects are achieved through the maintenance of immune homeostasis.
面对全球老龄化社会，维持老年人的健康和生活质量非常重要。与年龄相关的肌肉质量和力量丧失，即肌肉减少症，会严重降低生活质量并增加各种疾病的风险。在本研究中，我们研究了橙皮苷（HES）对炎症衰老的抑制作用，旨在评估其作为肌肉减少症治疗方法的潜在用途。我们研究了相当于人类70岁及以上的22 - 26月龄患有与衰老相关肌肉减少症的小鼠，以及3 - 6月龄的年轻小鼠。每天给予HES 8周可使老年小鼠的肌肉质量和力量增加，并增大其纤维尺寸。HES还恢复了因衰老而被破坏的免疫稳态，如M1/M2巨噬细胞比例失衡。此外，我们发现HES通过增加老年小鼠胰岛素样生长因子（IGF）-1的表达来调节AKT/雷帕霉素哺乳动物靶蛋白/叉头框蛋白3a信号通路，从而改善肌肉减少症。因此，HES是老年人肌肉减少症的一种有前景的候选抑制剂，其作用是通过维持免疫稳态来实现的。
