Zhang Henan, Zhang Jingsong, Liu Yanfang, Tang Chuanhong
Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, Shanghai 201403, China.
Foods. 2023 Aug 7;12(15):2975. doi: 10.3390/foods12152975.
has served as a valuable food supplement and medicinal ingredient with outstanding active compounds that are essential for human protection against chronic diseases. Modern pharmacology studies have proven that β-d-glucan exhibits versatile biological activities, such as immunomodulatory, antitumor, antioxidant, and antiviral properties, as well as gut microbiota regulation. As a promising polysaccharide, β-d-glucan is widely used in the prevention and treatment of various diseases. In recent years, the extraction, purification, structural characterization, and pharmacological activities of polysaccharides from the fruiting bodies, mycelia, spores, and fermentation broth of species have received wide attention from scholars globally. Unfortunately, comprehensive studies on the preparation, structure and bioactivity, toxicology, and utilization of β-d-glucans from species still need to be further explored, which may result in limitations in future sustainable industrial applications of β-d-glucans. Thus, this review summarizes the research progress in recent years on the physicochemical properties, structural characteristics, and bioactivity mechanisms of β-d-glucan, as well as its toxicological assessment and applications. This review is intended to provide a theoretical basis and reference for the development and application of β-d-glucan in the fields of pharmaceuticals, functional foods, and cosmetics.
它作为一种有价值的食物补充剂和药用成分，含有对人类预防慢性病至关重要的杰出活性化合物。现代药理学研究已证明，β - d - 葡聚糖具有多种生物活性，如免疫调节、抗肿瘤、抗氧化和抗病毒特性，以及对肠道微生物群的调节作用。作为一种有前景的多糖，β - d - 葡聚糖被广泛用于各种疾病的预防和治疗。近年来，来自该物种子实体、菌丝体、孢子和发酵液的多糖的提取、纯化、结构表征和药理活性受到了全球学者的广泛关注。不幸的是，关于该物种β - d - 葡聚糖的制备、结构与生物活性、毒理学及利用的全面研究仍有待进一步探索，这可能会限制β - d - 葡聚糖未来在可持续工业应用中的发展。因此，本综述总结了近年来关于β - d - 葡聚糖的物理化学性质、结构特征、生物活性机制及其毒理学评估和应用的研究进展。本综述旨在为β - d - 葡聚糖在制药、功能性食品和化妆品领域的开发与应用提供理论依据和参考。
