Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, Poland.
Student's Scientific Group in Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, Poland.
Int J Mol Sci. 2023 Jul 28;24(15):12078. doi: 10.3390/ijms241512078.
Salivary myeloperoxidase (MPO) is a key mediator of the oral immune system, acting as an enzyme that utilises HO to generate molecules with high bactericidal activity. While MPO determination in plasma is quite common, the use of saliva is still rare. Our systematic review was designed to answer the question "Are salivary levels of myeloperoxidase altered in patients with systemic diseases?". Following the inclusion and exclusion criteria, we included twenty-six studies. Altered MPO levels in saliva were most commonly found in patients with cardiovascular and gastrointestinal diseases. Most studies concerned unstimulated whole saliva, and only a few of them stimulated, mainly by chewing paraffin. Enzyme-linked immunosorbent assay (ELISA) was the most common method for determination of MPO concentrations in saliva. Increased salivary MPO levels were more often observed for inflammatory diseases, except patients with inflammatory bowel diseases who were eligible for biologic therapy. In conclusion, MPO could be altered in the saliva of patients with systematic diseases, especially cardiovascular or gastrointestinal diseases. However, further investigations are recommended to validate these outcomes.
唾液髓过氧化物酶 (MPO) 是口腔免疫系统的关键介质，作为一种利用 HO 生成具有高杀菌活性的分子的酶。虽然血浆中 MPO 的测定相当常见，但唾液的使用仍然很少。我们的系统评价旨在回答“系统性疾病患者的唾液髓过氧化物酶水平是否改变？”这个问题。根据纳入和排除标准，我们纳入了 26 项研究。唾液中 MPO 水平的改变在心血管和胃肠道疾病患者中最为常见。大多数研究涉及未刺激的全唾液，只有少数研究是通过咀嚼石蜡来刺激，主要是通过咀嚼石蜡。酶联免疫吸附试验 (ELISA) 是最常用的测定唾液 MPO 浓度的方法。除了有资格接受生物治疗的炎症性肠病患者外，炎症性疾病患者的唾液 MPO 水平升高更为常见。总之，系统性疾病患者的唾液 MPO 可能会发生改变，尤其是心血管疾病或胃肠道疾病患者。然而，建议进一步研究以验证这些结果。
