Huang Kaiyuan, El-Seedi Hesham R, Xu Baojun
Food Science and Technology Program, Department of Life Sciences, BNU-HKBU United International College, Zhuhai, China.
Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, China.
Curr Res Food Sci. 2022 Nov 5;5:2190-2203. doi: 10.1016/j.crfs.2022.10.029. eCollection 2022.
Murrill (AbM) is a medical mushroom which has huge potential commercial value with various health-promoting functions. However, the chemical composition and therapeutic mechanisms of AbM have not been concluded systematically yet. Thus, this study aims to comprehensively summarize the phytochemical profiles and thoroughly characterize the health promotion effects such as the antitumor and antidiabetic impact of AbM in and . The AbM consists of abundant bioactive substances; polysaccharides, lipids including ergosterol, sterols, proteins, vitamin B, C and D, and phenolic compounds. Several studies have claimed that Murrill polysaccharides (AbMP) had immunoregulation, anti-inflammatory, hepatoprotective, and antitumor function both and . Meanwhile, AbM extracts were thought to cure diabetes and bacterial infection, exhibiting anticarcinogenic and antimutagenic functions. But some principles behind health-promoting effects have not been clarified. Additionally, AbM related clinical trials are limited and further discovery need to be conducted. Therefore, this paper has concluded the health promotion impact with corresponding mechanisms of AbM and indicated its potential medical usage as functional food in the future.
穆里尔香菇（糙皮侧耳）是一种具有巨大潜在商业价值且具备多种促进健康功能的药用蘑菇。然而，糙皮侧耳的化学成分和治疗机制尚未得到系统总结。因此，本研究旨在全面总结其植物化学特征，并深入表征糙皮侧耳在体内外的健康促进作用，如抗肿瘤和抗糖尿病作用。糙皮侧耳含有丰富的生物活性物质，包括多糖、脂质（如麦角固醇）、甾醇、蛋白质、维生素B、C和D以及酚类化合物。多项研究表明，糙皮侧耳多糖在体内外均具有免疫调节、抗炎、保肝和抗肿瘤功能。同时，糙皮侧耳提取物被认为可治疗糖尿病和细菌感染，具有抗癌和抗诱变功能。但促进健康作用背后的一些原理尚未阐明。此外，与糙皮侧耳相关的临床试验有限，需要进一步探索。因此，本文总结了糙皮侧耳的健康促进作用及其相应机制，并指出了其未来作为功能性食品的潜在医学用途。
