Gruvberger B, Persson K, Björkner B, Bruze M, Dahlquist I, Fregert S
Contact Dermatitis. 1986 Jul;15(1):24-7. doi: 10.1111/j.1600-0536.1986.tb01256.x.
The preservative Kathon CG has become one of the most common sensitizers. It has, however, been difficult to explain the sensitization and to assess the clinical relevance of the contact allergy, partly due to lack of specification of the preservative in products. A high-performance liquid chromatography method was used to demonstrate Kathon CG in 123 commercial products of both "leave on" and "rinse off" types. 38 of these contained Kathon CG in the range of 1-15 ppm of active ingredients. There were no differences between "leave on" and "rinse off" products concerning the relative number of products containing Kathon CG and the concentrations of the preservative.
防腐剂凯松CG已成为最常见的致敏原之一。然而，由于产品中防腐剂的规格缺乏明确说明，一直难以解释致敏情况并评估接触性过敏的临床相关性。采用高效液相色谱法在123种“免洗型”和“冲洗型”商用产品中检测凯松CG。其中38种产品的活性成分中凯松CG含量在1 - 15 ppm范围内。在含有凯松CG的产品相对数量以及防腐剂浓度方面，“免洗型”和“冲洗型”产品之间没有差异。
