Department of Medical Laboratory Science, Bingham University Karu, Nasarawa State, Nigeria.
Department of Pharmacology & Toxicology, Usmanu Danfodiyo University, Sokoto, Nigeria.
Ethiop J Health Sci. 2023 May;33(3):441-450. doi: 10.4314/ejhs.v33i3.7.
Diabetes mellitus is among the most prevalent and costly chronic diseases in the world. Unfortunately, immediate prospects for a cure are not available. We aimed to determine the in vivo antidiabetic activity, histologic, and biochemical effect of Balanites aegyptiaca fruit extract on alloxan-induced diabetes in Wistar rats.
Thirty-six Wistar rats were allotted into six groups (n=6). Group I was normal control. Group II was induced with diabetes but not treated.Groups III-V were induced with diabetes and treated with 100, 200, and 300 mg/kg extracts while Group VI was treated with Metformin once daily for 14 days. Animals were euthanized, and blood samples were collected for biochemical assays. The liver, kidney, pancreas, and testis were excised and processed by the paraffin wax method.
Oral administration of BA extract significantly (P<0.05) reduced blood glucose, liver enzymes, and creatinine levels in diabetic animals. The extract also improved the body weights of diabetic animals and microscopic anatomy of the pancreas, testis, liver, and kidney parenchyma compared to the control.
Balanites aegyptiaca phytochemicals reduced blood glucose level and improved the histology of the liver, kidney, pancreas, and testis. Further study is recommended to identify the phytochemicals and mechanism of action.
糖尿病是世界上最普遍和昂贵的慢性疾病之一。不幸的是，目前还没有治愈的方法。我们旨在确定非洲吊灯树果实提取物对链脲佐菌素诱导的糖尿病大鼠的体内抗糖尿病活性、组织学和生化作用。
将 36 只 Wistar 大鼠分为六组（每组 6 只）。第 I 组为正常对照组。第 II 组为糖尿病诱导组，但未治疗。第 III-V 组为糖尿病诱导组，分别用 100、200 和 300mg/kg 提取物治疗，第 VI 组则每日给予二甲双胍治疗 14 天。处死动物，采集血液样本进行生化分析。取出肝脏、肾脏、胰腺和睾丸，用石蜡包埋法进行处理。
BA 提取物的口服给药显著（P<0.05）降低了糖尿病动物的血糖、肝酶和肌酐水平。与对照组相比，提取物还改善了糖尿病动物的体重和胰腺、睾丸、肝脏和肾脏实质的显微镜解剖结构。
非洲吊灯树植物化学物质降低了血糖水平，并改善了肝脏、肾脏、胰腺和睾丸的组织学。建议进一步研究以鉴定其植物化学成分和作用机制。
