Shin You Kyoung, Seol Geun Hee
Department of Basic Nursing Science, College of Nursing, Korea University, Seoul, Republic of Korea.
BK21 FOUR Program of Transdisciplinary Major in Learning Health Systems, Graduate School, Korea University, Seoul, Republic of Korea.
Front Pharmacol. 2023 Jul 28;14:1233977. doi: 10.3389/fphar.2023.1233977. eCollection 2023.
Mild cognitive impairment (MCI) is a major public health challenge with an increasing prevalence. Although the mechanisms underlying the development of MCI remain unclear, MCI has been reported to be associated with oxidative stress, inflammatory responses, and endothelial dysfunction, suggesting that agents that reduce these factors may be key to preventing MCI. Currently, no agents have been approved for the treatment of MCI, with the efficacy of commonly prescribed cholinesterase inhibitors remaining unclear. Relatively safe natural products that can prevent the development of MCI are of great interest. Linalyl acetate (LA), the major component of clary sage and lavender essential oils, has been shown to have a variety of pharmacological effects, including anti-hypertensive, anti-diabetic, neuroprotective, anti-inflammatory, and antioxidant properties, which may have the potential for the prevention of MCI. The present review briefly summarizes the pathogenesis of MCI related to oxidative stress, inflammatory responses, and endothelial dysfunction as well as the benefits of LA against these MCI-associated factors. The PubMed and Google Scholar databases were used to search the relevant literature. Further clinical research may lead to the development of new strategies for preventing MCI, particularly in high-risk populations with oxidative stress, inflammatory responses, and endothelial dysfunction (e.g., patients with hypertension and/or diabetes mellitus).
轻度认知障碍（MCI）是一项日益普遍的重大公共卫生挑战。尽管MCI发生发展的潜在机制尚不清楚，但据报道MCI与氧化应激、炎症反应和内皮功能障碍有关，这表明减少这些因素的药物可能是预防MCI的关键。目前，尚无药物被批准用于治疗MCI，常用的胆碱酯酶抑制剂的疗效仍不明确。能够预防MCI发生发展的相对安全的天然产物备受关注。乙酸芳樟酯（LA）是鼠尾草和薰衣草精油的主要成分，已被证明具有多种药理作用，包括抗高血压、抗糖尿病、神经保护、抗炎和抗氧化特性，这些特性可能具有预防MCI的潜力。本综述简要总结了与氧化应激、炎症反应和内皮功能障碍相关的MCI发病机制以及LA对这些与MCI相关因素的益处。使用PubMed和谷歌学术数据库检索相关文献。进一步的临床研究可能会促成预防MCI的新策略的开发，特别是在存在氧化应激、炎症反应和内皮功能障碍的高危人群中（例如高血压和/或糖尿病患者）。
