Mac Sweeney Eileen, Pieracci Ylenia, Popescu Vlad Sebastian, Angius Gianluca, Flamini Guido, Pistelli Luisa, Abate Giulia, Mastinu Andrea
Department of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Brescia, Italy.
Department of Pharmacy, University of Pisa, Pisa, Italy.
Chem Biodivers. 2025 Jul;22(7):e202403478. doi: 10.1002/cbdv.202403478. Epub 2025 Mar 4.
This study investigates the phytochemical profiles and antioxidant properties of three lavender essential oils (LEOs) from Lavandula angustifolia subsp. pyrenaica (DC.), Lavandula x intermedia Emeric ex Loisel cv Grosso, and Lavandula x intermedia Emeric ex Loisel cv Super, and compares them to a commercial one. LEOs were extracted by hydrodistillation, analyzed using gas chromatography-mass spectrometry, and tested for antioxidant effects on human SH-SY5Y neuroblastoma cells. The major components identified in all the four LEOs were linalool and linalyl acetate; however, in the commercial LEO differences in minor compounds and the presence of additives were found. Antioxidant activity assays revealed significant protection against H₂O₂-induced oxidative stress for hydrodistilled EOs, while the commercial EO showed no protective effect. Gene expression analysis indicated upregulation of antioxidant-related genes in cells treated with "Grosso" and "Super" LEOs. This research highlights the potential therapeutic applications of LEOs, with a particular emphasis on the differences between naturally derived oils and commercial variants.
本研究调查了来自狭叶薰衣草亚种比利牛斯薰衣草（DC.）、杂种薰衣草品种格罗索和杂种薰衣草品种超级的三种薰衣草精油（LEOs）的植物化学特征和抗氧化特性，并将它们与一种市售薰衣草精油进行比较。通过水蒸馏法提取薰衣草精油，采用气相色谱 - 质谱联用仪进行分析，并测试其对人SH - SY5Y神经母细胞瘤细胞的抗氧化作用。在所有四种薰衣草精油中鉴定出的主要成分是芳樟醇和乙酸芳樟酯；然而，在市售薰衣草精油中发现了次要化合物的差异以及添加剂的存在。抗氧化活性测定表明，水蒸馏法提取的精油对H₂O₂诱导的氧化应激具有显著的保护作用，而市售精油则没有保护作用。基因表达分析表明，用“格罗索”和“超级”薰衣草精油处理的细胞中抗氧化相关基因上调。本研究突出了薰衣草精油的潜在治疗应用，特别强调了天然来源的精油与市售变体之间的差异。
