Kowaleski Shane J, Hurmis Christina S, Coleman Carvin N, Philips Kieli D, Najor Nicole A
Biology Department, University of Detroit Mercy.
MicroPubl Biol. 2023 Jul 28;2023. doi: 10.17912/micropub.biology.000899. eCollection 2023.
protein She9 is localized to the inner mitochondrial membrane and is required for normal mitochondrial morphology. While deletion mutants of ( ) are viable and display large ring-like mitochondrial structures, the molecular function of is still unknown. We report a decreased growth of cells during a diauxic shift, where mitochondria are primarily employing oxidative phosphorylation to generate ATP versus the alternative mechanism of glycolysis in high glucose conditions. Further bioinformatics analysis reveal putative functional protein associations, and proposes a model to aid in the understanding of the molecular function of She9.
蛋白质She9定位于线粒体内膜，是正常线粒体形态所必需的。虽然（ ）的缺失突变体是可行的，并显示出大的环状线粒体结构，但其分子功能仍然未知。我们报告了在二次生长转换期间（ ）细胞的生长减缓，在此期间线粒体主要利用氧化磷酸化来产生ATP，而在高糖条件下则采用糖酵解的替代机制。进一步的生物信息学分析揭示了假定的功能性蛋白质关联，并提出了一个模型以帮助理解She9的分子功能。
