Auerbach O, Garfinkel L
Dig Dis Sci. 1986 Oct;31(10):1014-20. doi: 10.1007/BF01300252.
Histologic alterations in the epithelium of the ducts and exocrine portions of the parenchyma and thickening of the walls of the arterioles and arteries in the pancreas in relation to smoking habits was studied in 22,344 slides from 560 autopsied subjects. Only 5.4% of the nonsmokers had medium to high percentages of ductal cells with atypical nuclei. This rose to 50.7% in light smokers and to 74.9% in 40+ a day smokers. Advanced findings (increased numbers) of cells with atypical nuclei were found in the acinar cells of the parenchyma in only 1.8% of nonsmokers; 11.4% in less than 20 cigarettes a day smokers; 29.2% in 20-39 a day smokers; and 69.1% in 40+ a day smokers. Moderate or advanced hyaline thickening of arterioles in 12.8% of the nonsmokers increased to 74.4% in the heaviest smoking group. A similar relationship was observed for fibrous thickening in the arteries. Coffee drinking was not related to histologic alterations in the cells within the pancreas.
在对560名尸检对象的22344张切片进行研究时，观察了胰腺导管和实质外分泌部分上皮的组织学改变以及胰腺中小动脉和动脉壁增厚与吸烟习惯之间的关系。只有5.4%的不吸烟者有中等至高比例的具有非典型核的导管细胞。这一比例在轻度吸烟者中升至50.7%，在每天吸烟40支及以上者中升至74.9%。在实质腺泡细胞中，只有1.8%的不吸烟者发现有高级别（数量增加）的具有非典型核的细胞；每天吸烟少于20支者中这一比例为11.4%；每天吸烟20 - 39支者中为29.2%；每天吸烟40支及以上者中为69.1%。12.8%的不吸烟者出现小动脉中度或重度透明样增厚，在吸烟最严重的组中这一比例增至74.4%。在动脉的纤维性增厚方面也观察到类似关系。喝咖啡与胰腺内细胞的组织学改变无关。
