CRY1 多态性与替代健康饮食指数（AHEI）在超重和肥胖女性心血管风险因素中的相互作用：一项横断面研究。
The interaction between CRY1 Polymorphism and Alternative Healthy Eating Index (AHEI) on cardiovascular risk factors in overweight women and women with obesity: a cross-sectional study.
机构信息
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
Department of Nutrition, Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.
出版信息
BMC Endocr Disord. 2023 Aug 14;23(1):172. doi: 10.1186/s12902-023-01429-9.
BACKGROUND
According to some studies, diet can be interaction with CRY1 polymorphism and may be related to obesity and the risk of cardiovascular diseases (CVD). So, this study examined the interaction between CRY1 polymorphism and AHEI on cardiovascular risk factors in overweight women and women with obesity.
METHODS
This cross-sectional study was performed on 377 Iranian women with overweight and obesity aged 18-48(BMI ≥ 25 kg/m). Dietary intake was evaluated by the use of a food frequency questionnaire (FFQ) with 147 items. The AHEI was calculated based on previous studies. Anthropometric and biochemical measurements were assessed and the bioelectrical impedance analysis method was used for body analysis. The rs2287161 was genotyped by the restriction fragment length polymorphism (PCR-RFLP) method. Objects were divided into three groups based on rs2287161 genotypes.
RESULTS
Our findings determined that the prevalence of the C allele was 51.9% and the G allele was 48.0%. The mean age and BMI were 36.6 ± 9.1years and 31 ± 4 kg/m respectively. After controlling for confounders (BMI, age, total energy intake, and physical activity), this study demonstrated that there was a significant interaction between CC genotype and adherence to AHEI on odds of hyper LDL (OR = 1.94, 95% CI = 1.24-3.05, P for interaction = 0.004), hypertension (OR = 1.80, 95% CI = 1.11-2.93, P for interaction = 0.01) and hyperglycemia (OR = 1.56, 95% CI = 0.98-2.47, P for interaction = 0.05).
CONCLUSIONS
This study indicated that adherence to AHEI can reduce the odds of hyper LDL, hypertension, and hyperglycemia in the CC genotype of rs2287161.
背景
根据一些研究，饮食可能与 CRY1 多态性相互作用，并且可能与肥胖和心血管疾病 (CVD) 风险有关。因此，本研究旨在探讨 CRY1 多态性与 AHEI 在超重和肥胖女性心血管危险因素中的交互作用。
方法
本横断面研究纳入了 377 名年龄在 18-48 岁（BMI≥25kg/m）的伊朗超重和肥胖女性。采用包含 147 项的食物频率问卷（FFQ）评估膳食摄入量。AHEI 根据先前的研究进行计算。评估了人体测量学和生化指标，并使用生物电阻抗分析方法进行了身体分析。rs2287161 采用聚合酶链反应-限制性片段长度多态性 (PCR-RFLP) 方法进行基因分型。根据 rs2287161 基因型将对象分为三组。
结果
我们发现 C 等位基因的患病率为 51.9%，G 等位基因的患病率为 48.0%。平均年龄和 BMI 分别为 36.6±9.1 岁和 31±4kg/m。在控制了混杂因素（BMI、年龄、总能量摄入和体力活动）后，本研究表明，CC 基因型与 AHEI 依从性之间存在显著的交互作用，可增加 LDL 升高（OR=1.94，95%CI=1.24-3.05，P 交互=0.004）、高血压（OR=1.80，95%CI=1.11-2.93，P 交互=0.01）和高血糖（OR=1.56，95%CI=0.98-2.47，P 交互=0.05）的风险。
结论
本研究表明，AHEI 依从性可降低 rs2287161 的 CC 基因型患者 LDL 升高、高血压和高血糖的风险。
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