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纳米技术在膀胱癌诊断和治疗药物输送中的应用。

Application of nanotechnology in bladder cancer diagnosis and therapeutic drug delivery.

机构信息

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.

Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

出版信息

J Mater Chem B. 2023 Sep 13;11(35):8368-8386. doi: 10.1039/d3tb01323e.

Abstract

Bladder cancer (BC) is one of the most common malignant tumors in the urinary system, and its high recurrence rate is a great economic burden to patients. Traditional diagnosis and treatment methods have the disadvantages of insufficient targeting, obvious side effects and low sensitivity, which seriously limit the accurate diagnosis and efficient treatment of BC. Due to their small size, easy surface modification, optical properties such as plasmon resonance, and surface enhanced Raman scattering, good electrical conductivity and photothermal conversion properties, nanomaterials have great potential application value in the realization of specific diagnosis and targeted therapy of BC. At present, the application of nanomaterials in the diagnosis and treatment of BC is attracting great attention and achieving rich research results. Therefore, this paper summarizes the recent research on nanomaterials in the diagnosis and treatment of BC, clarifies the existing advantages and disadvantages, and provides theoretical guidance for promoting the accurate diagnosis and efficient treatment of BC.

摘要

膀胱癌(BC)是泌尿系统中最常见的恶性肿瘤之一,其高复发率给患者带来了巨大的经济负担。传统的诊断和治疗方法存在靶向性不足、副作用明显、灵敏度低等缺点,严重限制了 BC 的准确诊断和有效治疗。由于纳米材料具有尺寸小、易于表面修饰、等离子体共振等光学特性、良好的导电性和光热转换性能,因此在实现 BC 的特异性诊断和靶向治疗方面具有巨大的潜在应用价值。目前,纳米材料在 BC 的诊断和治疗中的应用引起了广泛关注,并取得了丰富的研究成果。因此,本文总结了纳米材料在 BC 诊断和治疗中的最新研究进展,阐明了其现有的优缺点,为推动 BC 的准确诊断和有效治疗提供了理论指导。

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