Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States.
ACS Nano. 2023 Sep 12;17(17):16291-16307. doi: 10.1021/acsnano.3c06564. Epub 2023 Aug 16.
The conception, synthesis, and invention of a nanostructure, now known as the spherical nucleic acid, or SNA, in 1996 marked the advent of a new field of chemistry. Over the past three decades, the SNA and its analogous anisotropic equivalents have provided an avenue for us to think about some of the most fundamental concepts in chemistry in new ways and led to technologies that are significantly impacting fields from medicine to materials science. A prime example is colloidal crystal engineering with DNA, the framework for using SNAs and related structures to synthesize programmable matter. Herein, we document the evolution of this framework, which was initially inspired nature, and describe how it now allows researchers to chart paths to move it, as programmable matter with real-world significance is envisioned and created.
1996 年，一种被称为球形核酸（SNA）的纳米结构的构想、合成和发明标志着一个新化学领域的出现。在过去的三十年中，SNA 及其类似的各向异性等价物为我们提供了一种新的途径，以新的方式思考化学中一些最基本的概念，并导致了对从医学到材料科学等领域产生重大影响的技术。一个主要的例子是使用 DNA 的胶体晶体工程，这是使用 SNA 和相关结构来合成可编程物质的框架。本文记录了这一框架的演变，该框架最初受到自然的启发，并描述了它现在如何使研究人员能够规划路径来推动它，因为可预见和创造具有现实意义的可编程物质。
